SURVIVAL FUNCTIONS IN 40-59 YEAR OLD MALE COHORTS ACCORDING TO THE PRESENCE OF ARTERIAL HYPERTENSION AND/OR MYOCARDIAL INFARCTION AND VARIOUS HIGH DENSITY LIPOPROTEIDES CONCENTRATIONS (BY THE 30-YEARS OBSERVATION)

Abstract

Aim. To study interrelations of survival functions with the level of high-density lipoproteides cholesterol (CL HDL) in cohorts of 40-59 y. o. males with various cardiovascular disease status (CVD).

Material and methods. Randomly assigned 4 representative male groups aged 40-59 y. o. of Magnitogorsk district differed by the health status: almost healthy (n=174), hypertensive (n=149), with anamnesis of myocardial infarction (n=198), patients with infarction and arterial hypertension (n=154), – for prospective observation. The endpoint was death. To the cohorts mentioned the Cox model was applied for the 30-years survival functions, and the parameter revealed that explains the most significant influence on survival – HDL cholesterol, and the survival functions established for various levels of CL HDL. To compare survival rate in time points, endowment periods in different CL HDL groups, the relativity fields of survival functions were calculated using Kholmogorov-Smirnov criterion.

Results. The increase of CL HDL concentrations from 0,3 to 1,7 mmol/L in the cohorts mentioned is followed by significant increase of survival rate.

Conclusion. Characteristics of 30-years survival rate in the cohorts studied of 40-59 y.o. males with the increase of CL HDL demonstrates heterogeneity by the start, end and duration of the periods of significant differences of endowment graphs. The influence of baseline CL HDL concentrations on the 30-years survival functions among men not related to CVD. The influence of CL HDL on 30-year survival rate depends on CVD status and the disease periods.