THE GENES ASSOCIATED WITH LIPID METABOLISM DISORDERS AND WITH BLOOD PRESSURE REGULATION, AND PSYCHOVEGETATIVE CHANGES IN THE YOUNG ALMOST HEALTHY PERSONS
https://doi.org/10.15829/1728-8800-2016-6-53-57
Abstract
Aim. To assess the relation of polymorphism of the genes APOC3, PON1, AGT, AGTR1 and psychovegetative disorders in young, relatively healthy persons.
Material and methods. Totally, 75 healthy volunteers included, white race, aged 20-25 y.o. Psychovegetative status was assessed with tests for panic attacks revealing, anxiety level assessment, as with the questionnaire for vegetovascular dystony. The inclusion criteria was organic pathology of cardiovascular and central nervous system. Genes polymorphism was identified with the method of pyrosequencing of desoxyribonucleic acid with the genetic analysis equipment “PyroMark Q24”
Results. The presence of vegetovascular dystony, panic attacks and increased level of anxiety was mostly associated with the presence of T polymorphism -482 C>T gene APOC3, allele М polymorphism L55M А>Т gene PON1 and allele А — polymorphism А1666С А>С gene AGTR1. Conclusion. There is relation of genes polymorphism playing role in lipids metabolism and arterial pressure regulation, with psychovegetative status of the young, relatively healthy persons.
About the Authors
Yu. G. Shvarts
V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical University
Russian Federation
Russian Federation
A. Yu. Elkina
V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical University
Russian Federation
Russian Federation
N. S. Akimova
V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical University
Russian Federation
Russian Federation
T. V. Martynovich
V. I. Razumovskiy Research Institute of Cardiology of Saratov Medical University
Russian Federation
Russian Federation
E. A. Fedotov
Медицинский Di центр, ООО
Russian Federation
Russian Federation
References
1. Allgulander C. Anxiety as a risk factor in cardiovascular disease. Pub Med 2016; 29(1): 13-7.
2. Cathcart K, Patel A, Dies H, et al. Effect of Cholesterol on the Structure of a Five-Component Mitochondria-Like Phospholipid Membrane. Pub Med; 2015; 5(4): 664-84.
3. Wang Z. SNP's, protein structure and disease. Hum Mutat 2001; 17: 263-70.
4. Otowa T, Hek K, Lee M, et al. Meta-analysis of genome-wide association studies of anxiety disorders. JAMA Psychiatry 2015; 72(7): 642-50.
5. Mironov KO, Dunaeva EA, Dribnohodova OP. Detection of genetic polymorphisms using genetic analysis systems based on pyrosequencing. Modern medical technologies 2011; 3: 39-41. Russian (Миронов К. О., Дунаева Е. А., Дрибноходова О. П. Детекция генетических полиморфизмов с помощью систем генетического анализа на основе пиросеквенирования. Современные медицинские технологии 2011; 3: 39-41).
6. Olivieri O, Martinelli N, Girelli G, et al. Apolipoprotein C III predicts cardiovascular mortality in severe coronary artery disease and is associated with an enhanced thrombin generation. J Thromb Haemost 2010; 8: 463-71.
7. Barrett HR, Chan DC, Ooi EMM, et al. Apolipoprotein C III: understanding an emerging risk factor. Clin Sci 2008; 114: 611-24.
8. Crosby J, Peloso GM, Auer PL, et al. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014; 371(1): 22-31.
9. Mendivil CO, Rimm EB, Furtado J, et al. Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease. Circulation 2011; 124(19): 2065-72.
10. Kurdjukov ID. Paraoxonase-1: genetic, biochemical and toxicological aspects. Toxicological Review 2011; 1:48-55. Russian (Курдюков И. Д. Параоксоназа-1: генетические, биохимические и токсикологические аспекты. Токсикологический вестник 2011; 1: 48-55).
11. Aviram M, Rosenblat M. Paraoxonases and cardiovascular disease: pharmacological and nutritional influences. Curr Opin Lipidol 2005; 16(4): 393-9.
12. Mackness MI, Arrol S, Durrington PN. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett 1991; 286(1): 152-4.
13. Fursova MV. Complex treatment of panic disorder. Medical Scientific J 2006; 3: 84-6. Russian (Фурсова М. В. Комплексное лечение панического расстройства. Медицинский научно-практический журнал 2006; 3: 84-6).
14. Terri L, Kathryn P. The Experience of Panic Symptoms across Racial Groups in a Student Sample. J Anxiety Disord 2010; 24(8): 873-8.
15. Mouhamed HD, Ezzaher A, Mechri A, et al. Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms. Environ. Health Prev Med 2012; 17(4): 316-21.
16. Sethupathy P, Borel C, Gagnebin M, et al. Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet 2007; 81(2): 405-13.
Review
For citations:
Shvarts Yu.G., Elkina A.Yu., Akimova N.S., Martynovich T.V., Fedotov E.A. THE GENES ASSOCIATED WITH LIPID METABOLISM DISORDERS AND WITH BLOOD PRESSURE REGULATION, AND PSYCHOVEGETATIVE CHANGES IN THE YOUNG ALMOST HEALTHY PERSONS. Cardiovascular Therapy and Prevention. 2016;15(6):53-57. (In Russ.) https://doi.org/10.15829/1728-8800-2016-6-53-57
Views:
1100
Email this article 
