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THE STUDY OF LONGEVITY: RECENT UPDATES AND FURTHER DIRECTION. PART 1

https://doi.org/10.15829/1728-8800-2017-3-75-80

Abstract

The increase  of life duration leads to a sharp growth of the older and senile persons number. Differences in chronological and biological ages, of the velocity of ageing in different persons, make it to study biological and genetic factors of longevity. In the series of reviews we summarize the results of studies in these  areas.  However, except the fundamental scientific interest, general ageing of population and longevity are related to medical and social issues on the geriatric care organization. Regardless  the  high interest,  longevity is still underinvestigated.  The review focuses on the wide spectrum of longevity issues — from genetics to medical and social problems.

About the Authors

Yu. V. Kotovskaya
Peoples’ Friendship University of Russia; N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”
Russian Federation

Moscow



О. N. Tkacheva
N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”
Russian Federation

Moscow



N. К. Runikhina
N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”
Russian Federation

Moscow



D. A. Kashtanova
N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”; National Research Center for Preventive Medicine of the Ministry of Health
Russian Federation

Moscow



S. A. Boytsov
Russian Cardiological Research-and-Production Complex of the Ministry of Health
Russian Federation

Moscow



References

1. Goldman DP, Cutler D, Rowe JW, et al. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff (Millwood) 2013; 32(10): 1698-705.

2. Martin GM. Genetic modulation of senescent phenotypes in Homo sapiens. Cell 2005; 120(4): 523-32.

3. Andersen SL, Sebastiani P, Dworkis DA, et al. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci 2012; 67(4): 395-405.

4. Sebastiani P, Sun FX, Andersen SL, et al. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health 2013; 1: 38.

5. Evans CJ, Ho Y, Daveson BA, et al. Place and cause of death in centenarians: a population-based observational study in England, 2001 to 2010. PLoS Med 2014; 11(6): e1001653.

6. Ailshire JA, Beltran-Sanchez HEM. Crimmins, Becoming centenarians: disease and functioning trajectories of older US Adults as they survive to 100. J Gerontol A Biol Sci Med Sci 2015; 70(2): 193-201.

7. Pushkova ES, Lenskaya LV. Longevity in Saint-Petersburg. Biomeditsinskiy Journal 2003; 4(29): 32-4. Russian (Пушкова Э. С., ленская л. В., долгожительство в Санкт-Петербурге. Биомедицинский журнал 2003; 4(29): 32-4).

8. Shabalin AV, Voevoda MI, Chernih NI, et al. Longevity — the model for study of ageing. Bulletin of SB RAMS 2006; 4(122): 11-21. Russian (Шабалин а. В., Воевода М. и., черных Н. и. и др. долгожительство — модель изучения процесса старения. Бюллетень СО РаМН 2006; 4(122): 11-21).

9. Denisova TP, Malinova LI, Cherevatova OM, et al. Age-dependent dynamics of screening metabolic parameters in long-livers and its biophysical estimation. Saratov Journal of Medical Scientific Research 2015; 11(1): 28-31. Russian (денисова т. П., Малинова л. и., череватова О. М. Возраст-зависимая динамика скрининговых метаболических параметров у долгожителей и ее биофизическая оценка. Саратовский научно-медицинский журнал 2015; 11(1): 28-31).

10. Schoenmaker M, de Craen AJ, de Meijer PH, et al. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet 2006; 14(1): 79-84.

11. Westendorp RG, van Heemst D, Rozing MP, et al. Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc 2009; 57(9): 1634-7.

12. Perls TT, Wilmoth J, Levenson R, et al. Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci U S A 2002; 99(12): 8442-7.

13. Atzmon G, Schechter C, Greiner W, et al. Clinical phenotype of families with longevity. J Am Geriatr Soc 2004; 52(2): 274-7.

14. Adams ER, Nolan VG, Andersen SL, et al. Centenarian offspring: start healthier and stay healthier. J Am Geriatr Soc 2008; 56(11): 2089-92.

15. Altmann-Schneider I, van der Grond J, Slagboom PE, et al. Lower susceptibility to cerebral small vessel disease in human familial longevity: the Leiden Longevity Study. Stroke 2013; 44(1): 9-14.

16. Lipton RB, Hirsch J, Katz MJ, et al, Exceptional parental longevity associated with lower risk of Alzheimer’s disease and memory decline. J Am Geriatr Soc 2010; 58(6): 1043-9.

17. Florez H, Ma Y, Crandall JP, et al. Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol A Biol Sci Med Sci 2011; 66(11): 1211-7.

18. Rajpathak SN, Liu Y, Ben-David O, et al. Lifestyle factors of people with exceptional longevity. J Am Geriatr Soc 2011; 59(8): 1509-12.

19. Beekman M, Nederstigt C, Suchiman HE, et al. Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A 2010; 107(42): 18046-9.

20. Sebastiani P, Solovieff N, Dewan AT, et al. Genetic signatures of exceptional longevity in humans. PLoS One 2012; 7(1): e29848.

21. Nebel A, Kleindorp R, Caliebe A, et al. A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech Ageing Dev 2011; 132(6-7): 324-30.

22. Milman S, Barzilai N. Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span. Cold Spring Harb Perspect Med 2015; 6(1): a025098.

23. Atzmon G, Pollin TI, Crandall J, et al. Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci 2008; 63(5): 447-53.

24. Atzmon G, Barzilai N, Surks MI, et al. Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. J Clin Endocrinol Metab 2009; 94(12): 4768-75.

25. Atzmon G, Cho M, Cawthon RM, et al. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A 2010; 107 Suppl 1: 1710-7.

26. Carmi S, Hui KY, Kochav E, et al. Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nat Commun 2014; 5: 4835.

27. Freudenberg-Hua Y, Freudenberg J, Vacic V, et al. Disease variants in genomes of 44 centenarians. Mol Genet Genomic Med 2014; 2(5): 438-50.

28. Bonafe M, Marchegiani F, Cardelli M, et al. Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. Eur J Hum Genet 2002; 10(5): 292-6.

29. Franceschi C, Olivieri F, Marchegiani F, et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev 2005; 126(2): 351-61.

30. Marchegiani F, Marra M, Spazzafumo L, et al. Paraoxonase activity and genotype predispose to successful aging. J Gerontol A Biol Sci Med Sci 2006; 61(6): 541-6.

31. Kojima T, Kamei H, Aizu T, et al. Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp Gerontol 2004; 39(11-12): 1595-8.

32. van Heemst D, Beekman M, Mooijaart SP, et al. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 2005; 4(2): 79-85.

33. Mecocci P, Polidori MC, Troiano L, et al. Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med 2000; 28(8): 1243-8.

34. Barzilai N, Atzmon G, Derby CA, et al. A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 2006; 67(12): 2170-5.

35. Kahn AJ. FOXO3 and related transcription factors in development, aging, and exceptional longevity. J Gerontol A Biol Sci Med Sci 2015; 70(4): 421-5.

36. Monsalve M, Olmos Y. The complex biology of FOXO. Curr Drug Targets 2011; 12(9):1322-50.

37. Lawrence RW, Evans DM, Cardon LR. Prospects and pitfalls in whole genome association studies. Philos Trans R Soc Lond B Biol Sci 2005; 360(1460): 1589-95.

38. Barzilai N, Gabriely I, Gabriely M, et al. Offspring of centenarians have a favorable lipid profile. J Am Geriatr Soc 2001; 49(1): 76-9.


Review

For citations:


Kotovskaya Yu.V., Tkacheva О.N., Runikhina N.К., Kashtanova D.A., Boytsov S.A. THE STUDY OF LONGEVITY: RECENT UPDATES AND FURTHER DIRECTION. PART 1. Cardiovascular Therapy and Prevention. 2017;16(3):75-80. (In Russ.) https://doi.org/10.15829/1728-8800-2017-3-75-80

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)