A VESSEL AGE. MECHANISMS OF VESSEL WALL AGEING. METHODS OF ASSESSMENT
https://doi.org/10.15829/1728-8800-2014-5-74-82
Abstract
The age is common risk factor for cardiovascular diseases (CVD). One of the main risk factors for ageing is biological age of vessels. For early prevention of CVD there must be screening methods of vessel age assessment in patients with the anamnesis prone to CVD. Main mechanisms of vessel ageing are oxidative stress, endothelial dysfunction, chronic inflammation, replication ageing and apoptosis of endothelial cells, damage of endothelial progenitory cells function, age dysregulation of circadian system. Understanding of the mechanisms that lead to ageing pathophysiological changes in vessels is important and is necessary for novel methods of pathogenetic treatment. As perspective – early prevention of CVD, achievement of healthy ageing, improve of life quality of older persons.
About the Authors
O. M. Drapkina
SBEI HPE First Moscow State Medical University n. a. I. M. Sechenov of the Ministry of Health, Moscow
Russian Federation
Russian Federation
tel./fax: +7 (910) 454-11-32
B. A. Mandzhieva
SBEI HPE First Moscow State Medical University n. a. I. M. Sechenov of the Ministry of Health, Moscow
Russian Federation
Russian Federation
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For citations:
Drapkina O.M., Mandzhieva B.A. A VESSEL AGE. MECHANISMS OF VESSEL WALL AGEING. METHODS OF ASSESSMENT. Cardiovascular Therapy and Prevention. 2014;13(5):74-82. (In Russ.) https://doi.org/10.15829/1728-8800-2014-5-74-82
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