GUT ENTEROBIOTA — A NEW PLAYER IN ATHEROSCLEROSIS PATHOGENESIS
https://doi.org/10.15829/1728-8800-2014-6-56-61
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Abstract
The article provides a review of contemporary literature, which generalizes experimental and clinical data on the role of gut microbiota in atherosclerosis development. Gut microflora can be named a marker of the macroorganism condition, reacting on age-related, physiological, dietic, climatogeoraphic factors with its changes of qualitative and quantitative compounds. It was shown that L-carnitine and choline being received with food, are utilized by microflora to synthetize trimethylamine, which then rapidly oxydized by flavinmonooxygenase of liver to trimethylamin-N-oxide, that causes atherosclerosis development and increases risk of cardiovscular diseases.
About the Authors
L. V. Egshatyan
FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health of Russian Federation, Moscow
Russian Federation
tel./fax: +7 (926) 860-79-55
Russian Federation
tel./fax: +7 (926) 860-79-55
O. N. Tkacheva
FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health of Russian Federation, Moscow
Russian Federation
Russian Federation
S. A. Boytsov
FSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health of Russian Federation, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Egshatyan L.V., Tkacheva O.N., Boytsov S.A. GUT ENTEROBIOTA — A NEW PLAYER IN ATHEROSCLEROSIS PATHOGENESIS. Cardiovascular Therapy and Prevention. 2014;13(6):56-61. (In Russ.) https://doi.org/10.15829/1728-8800-2014-6-56-61
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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)
ISSN 2619-0125 (Online)
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