Efficacy, safety of combined perindopril and indapamide low-dose therapy in patients with arterial hypertension and metabolic syndrome
Abstract
Aim. To study clinical, hemodynamic, and metabolic effects of 12-week therapy with Noliprel® (perindopril 2 mg plus indapamide 0.625 mg) in patients with arterial hypertension (AH) and metabolic syndrome (MS).
Material and methods. Twenty-five patients with AH and MS were enrolled in the study. At baseline, as well as after 12 weeks of Noliprel® and Noliprel Forte® therapy, 24-hour blood pressure monitoring (BPM), metabolic and hemostatic parameters’ assessments were performed.
Results. Twelve-week therapy with Noliprel® and Noliprel Forte® resulted in decrease of circadian BP, day- and night-time pressure load indices, and BP bi-phase profile normalization. Treatment with Noliprel® and Noliprel Forte® did not significantly influence plasma levels of lipids, glucose, or insulin. Initially increased platelet aggregation substantially improved during the treatment.
Conclusion. The results obtained demonstrate good antihypertensive effects during the whole day, and metabolic neutrality for both medications.
About the Authors
O. N. Andreeva
Russian State Medical University
Russian Federation
Russian Federation
I. M. Korochkin
Russian State Medical University
Russian Federation
Russian Federation
N. P. Rechnova
Clinical Hospital No. 13, Moscow
Russian Federation
Russian Federation
V. Yu. Pibovarov
Russian State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Andreeva O.N., Korochkin I.M., Rechnova N.P., Pibovarov V.Yu. Efficacy, safety of combined perindopril and indapamide low-dose therapy in patients with arterial hypertension and metabolic syndrome. Cardiovascular Therapy and Prevention. 2005;4(3, ч.I):46-52. (In Russ.)
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