Angiotensin receptor-1 antagonist eprosartan in patients with mild to moderate arterial hypertension
Abstract
Aim. To study clinical effectiveness of eprosartan mesylate in treating patients with Stage I-II arterial hypertension (AH).
Material and methods. In total, 28 patients (20 males, 8 females) with Stage I-II AH, risk 2-3, aged 28-56 years (mean age 40.0±1.3), were examined. All participants received eprosartan monotherapy (600 mg once per day) for 8 weeks. At baseline and 8 weeks later, 24-hour ECG and blood pressure (BP) monitoring, stress echocardiography with counting test, cognitive functions and quality of life (SF-36 Questionnaire) assessments were performed.
Results. Eprosartan monotherapy was associated with moderate antihypertensive and sympatholytic effects, decreased diastolic dysfunction during psycho-emotional stress, and no negative influence on cognitive processes.
Conclusion. Eprosartan could be used for treating patients with Stage I-II essential AH, whose professional activity demands intact superior neuro-psychic functions.
About the Authors
A. V. Shabalin
Novosibirsk State Medical Academy, Novosibirsk
Russian Federation
Russian Federation
E. N. Gulyaeva
Clinical Hospital No.1, Central Administration for execution control, Ministry of Justice of the Russian Federation, Kemerovo
Russian Federation
Russian Federation
A. S. Krikovtsov
Clinical Hospital No.1, Central Administration for execution control, Ministry of Justice of the Russian Federation, Kemerovo
Russian Federation
Russian Federation
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Review
For citations:
Shabalin A.V., Gulyaeva E.N., Krikovtsov A.S. Angiotensin receptor-1 antagonist eprosartan in patients with mild to moderate arterial hypertension. Cardiovascular Therapy and Prevention. 2005;4(6, ч.I):31-37. (In Russ.)
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