Bisoprolol and sotalol for maintaining sinus rhythm in patients with paroxysmal atrial fibrillation and chronic heart failure
Abstract
Aim. To compare sotalol and bisoprolol efficacy for post-cardioconversion sinus rhythm maintaining in patients with chronic heart failure (CHF) and paroxysmal atrial fibrillation (AF).
Material and methods. For 6 months, 45 patients (mean age 60.3±3.2 years) with non-rheumatic AF were observed. In individuals with CHF and paroxysmal AF, after restoring sinus rhythm, preventive antiarrhythmic therapy included sotalol (mean daily dose 160 mg; Group I, n=23) and bisoprolol (mean daily dose 7.5 mg; Group II, n=22).
Results. In one patient from Group II and 3 patients from Group I (4.5% and 13%, respectively), AF became permanent. CHF functional class decreased by 7% in Group I, and by 10.2% in Group II. Six-minute walking test results improved by 10.2% and 9.3%; left ventricular ejection fraction increased by 1.3% and 9.3%; left atrium size reduced by 2.1% and 6.8%, respectively. In sotalol group, functional activity of β-adrenoreceptors (β-AR) increased by 16.5% (р>0.05), in bisoprolol group, it significantly reduced by 34% (р<0.05). There was direct correlation between β-AR and heart rate (r=0.58, р<0.01), and inverse linear correlation between β-AR and physical stress tolerance improvement (r=-0.43, р<0.05).
Conclusion. Sotalol and bisoprolol were equally effective in maintaining restored sinus rhythm in patients with CHF and paroxysmal AF.
About the Authors
S. N. Tereshchenko
Moscow State Medico-Stomatological University
Russian Federation
Russian Federation
Yu. A. Uteshev
City Clinical Hospital No. 68, Moscow
Russian Federation
Russian Federation
M. N. Morozova
City Clinical Hospital No. 68, Moscow
Russian Federation
Russian Federation
N. G. Chuich
City Clinical Hospital No. 68, Moscow
Russian Federation
Russian Federation
A. G. Kochetov
Moscow State Medico-Stomatological University
Russian Federation
Russian Federation
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Review
For citations:
Tereshchenko S.N., Uteshev Yu.A., Morozova M.N., Chuich N.G., Kochetov A.G. Bisoprolol and sotalol for maintaining sinus rhythm in patients with paroxysmal atrial fibrillation and chronic heart failure. Cardiovascular Therapy and Prevention. 2005;4(6, ч.I):45-50. (In Russ.)
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