Vascular endothelium state in different types of antihypertensive treatment
Abstract
Aim. To study ozone therapy effects on blood biochemistry (NO metabolites, NOn-), pro6oxidant and anti-oxdant systems in arterial hypertension (AH) patients.
Material and methods. The study was focused on ozone therapy effects on metabolic activity of vascular endothelium and lipid peroxidation (LP) activity in 126 patients with stage I-II AH. The levels of NOn- in serum, malone dialdehyde in plasma and superoxide dismutase in red blood cells were measured.
Results. In Stage I-II AH, NOn- concentration was reduced, especially in Stage II AH. After one-month combined treatment, plasma NOn- level was similar to that in controls. As early as after first 7 days, ozone therapy resulted in significant LP activity reduction and increased antioxidant potential (AOP), comparing to standard treatment group.
Conclusion. Ozone therapy facilitates normalization of vascular endothelium NO-producing function, decrease in LP activity, and AOP restoration.
About the Authors
N. V. Kucherenko
Sanatorium “Zhemchuzhny”. Nakhodka
Russian Federation
Russian Federation
O. V. Nastradin
Vladivostok State Medical University. Vladivostok
Russian Federation
Russian Federation
E. V. Eliseeva
Vladivostok State Medical University. Vladivostok
Russian Federation
Russian Federation
E. S. Potapova
Vladivostok State Medical University. Vladivostok
Russian Federation
Russian Federation
V. A. Nevzorova
Vladivostok State Medical University. Vladivostok
Russian Federation
Russian Federation
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Review
For citations:
Kucherenko N.V., Nastradin O.V., Eliseeva E.V., Potapova E.S., Nevzorova V.A. Vascular endothelium state in different types of antihypertensive treatment. Cardiovascular Therapy and Prevention. 2008;7(1):29-32. (In Russ.)
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