Surrogate atherosclerosis markers in patients with stage I-II arterial hypertension
Abstract
Aim. То investigate the associations between cardiovascular remodeling, endothelial hemostasis and carotid (CA) and coronary artery (CorA) atherosclerosis in patients with high blood pressure.
Material andmethods. This controlled cohort study included 320 40—59-year-old patients with Stage I-II arterial hypertension (AH) and 75 healthy controls. The examination included Doppler echocardiography, carotid and middle cerebral artery dopplerography (evaluation of left ventricular hypertrophy (LVH), TV remodeling type, common carotid artery (CCA) intima-media thickness (IMT)), brachial artery (BA) reactive hyperemia test, coronary angiography, and C protein level measurement.
Results. CA and CorA atherosclerosis was observed in more than 50 % of AH patients, significantly more often than in controls. CA atherosclerosis was associated with IMT (r=0,61), LVH (0,34) and blood flow velocity in the middle cerebral artery (r “it.32): CorA atherosclerosis —with IMT (r=55), LVH(r=0,45), LV posteriorwall thickness (r=0,43), concentric TV geometry (r=0,28), C protein (r=-0,29) and impaired relaxation in BA reactive hyperemia test (rM!,31).
Conclusion. LVH and increased IMT are common surrogate markers of systemic atherosclerotic process. CorA atherosclerosis was associated with concentric :LV geometry and endothelial dysfunction, CA atherosclerosis — with reduced cerebral blood flow.
About the Authors
E. A. Grigoricheva
Ural State Medical Academy of Post-Diploma Education; State Research Center for Preventive Medicine
Russian Federation
Russian Federation
Chelyabinsk, Moscow
E. G. Volkova
Ural State Medical Academy of Post-Diploma Education; State Research Center for Preventive Medicine
Russian Federation
Russian Federation
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Review
For citations:
Grigoricheva E.A., Volkova E.G. Surrogate atherosclerosis markers in patients with stage I-II arterial hypertension. Cardiovascular Therapy and Prevention. 2009;8(1):15-19. (In Russ.)
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