Laboratory and genetic markers in coronary risk stratification
Abstract
Aim. То assess diagnostic effectiveness of laboratory and genetic markers in combination with traditional risk factors (RFs) for coronary heart disease (CHD) prediction.
Material and methods. In total, 131 patients with CHD, verified at coronary angiography, and 159 controls were examined. In all participants, the levels of the following laboratory markers were measured: lipid profile, lipoprotein (a), highly specific C-reactiveprotein (hs-CRP), D-dimer, fibrinogen, folic acidandB12 vitamin. Additionally, 29 polymorphisms of 27 genes, associated with CHD, were examined.
Results. Among laboratory markers, hs-CRP, lipoprotein (a) and D-dimer were independent CHD predictors. Polymorphisms of 4 genes (ApoE, PAI-1, GPIIIa, UCP2) were significantly associated with an increased CHD risk, after controlling for traditional RFs. For the model including traditional RFs, additional laboratory and genetic markers, AUC ROC was 88 %.
Conclusion. The combination oflaboratory and genetic markers with traditional RFs substantially improves prognostic quality of CHD risk assessment. Considering genotype and phenotype markers together is important for better understanding of their role in CHD pathogenesis.
About the Authors
G. I. Nazarenko
Medical Centre, Bank of Russia
Russian Federation
Russian Federation
Moscow
E. B. Kleymenova
Medical Centre, Bank of Russia
Russian Federation
Russian Federation
Moscow
N. N. Gushchina
Medical Centre, Bank of Russia
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Nazarenko G.I., Kleymenova E.B., Gushchina N.N. Laboratory and genetic markers in coronary risk stratification. Cardiovascular Therapy and Prevention. 2009;8(1):35-41. (In Russ.)
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