Early vascular remodeling role in arterial hypertension pathogenesis among young patients
Abstract
Aim. To investigate vascular wall stiffness in young patients, for examining early vascular remodeling role in arterial hypertension (AH) pathogenesis in young age. Material and methods. The study included 291 individuals: 169 normotensives and 122 AH patients aged 16-34 years. All participants underwent volume sphygmography (VaSera-1000, «Fukuda Denshi», Japan), blood pressure (BP) measurement in upper and lower extremity basins, elastic and muscular vessel elasticity assessment. Results. In young age, high elastic vessel stiffness was observed in 13.6% of normotensives, and in 50% of AH patients. For muscular vessels, this parameter was 11.2% and 35%, respectively. In systolo-diastolic AH, muscular vessel stiffness increased, in isolated systolic AH (ISAH) – elastic or elastic and muscular vessel stiffness is increased. About 50% of young ISAH individuals had increased BP on upper extremities only – «pseudo-hypertension». Conclusion. Early vascular remodeling plays an important role in AH pathogenesis among young people.
About the Authors
I. V. Milyagina
Smolensk State Medical Academy. Smolensk
Russian Federation
Russian Federation
V. A. Milyagin
Smolensk State Medical Academy. Smolensk
Russian Federation
Russian Federation
M. V. Grekova
Smolensk State Medical Academy. Smolensk
Russian Federation
Russian Federation
V. V. Kopteva
Смоленская государственная медицинская академия. Смоленск
Russian Federation
Russian Federation
References
1. Бойцов С.А. Что мы знаем о патогенезе артериальной гипертензии. Cons med 2004; 5: 315-9.
2. Гогин Е.Е. Гипертоническая болезнь: основы патогенеза, диагностика и выбор лечения. Cons med 2004; 5: 324-30.
3. O’Rourke M. Mechanical Principles in Arterial Disease. Hypertension 1995; 26: 2-9.
4. Boutouyrie P, Tropeano AI, Asmar R, et al. Aortic stiffness as an independent predictor of primary coronary events in hypertensive patients. Hypertension 2002; 39: 10-5.
5. Zervoudaki AI, Toutouzas PK. Remodeling of resistance vessels in essential hypertension. Hellenic J Cardiol 2003; 44: 116-24.
6. Бойцов С.А., Карпенко М.А., Линчак Р.М. В сб. Современные аспекты общей и военно-морской терапии. Труды военно-медицинской академии. Санкт-Петербург 2000; 24-34.
7. Benetos A, Okida K, Lajemi M, et al. Telomere length as an indicator of biological aging. Hypertension 2001; 37(Part 2): 381-5.
8. Blacher J, Asmar R, Djane S, et al. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999; 33: 1111-7.
9. Кочкина М.С., Затейщиков Д.А., Сидоренко Б.А. Измерение жесткости артерий и ее клиническое значение. Кардиология 2005; 1: 63-71.
10. O’Rourke MF, Vlachopoulos C, Graham RM. Spurious systolic hypertension in youth. Vasc Med 2000; 5(3): 141-5.
11. Wilkinson IB, Franklin SS, Hall IR, et al. Pressure amplification explains why pulse pressure is unrelated to risk in young subjects. Hypertension 2001; 38: 1461-6.
12. Albaladejo P, Copie X, Boutouyrie P, et al. Heart rate, arterial stiffness, and wave reflection in paced patients. Hypertension 2001; 38: 949-52.
13. Mahmud A, Feely J. Spurious systolic hypertension of youth: fit young men with elastic arteries. Am J Hypertens 2003; 16(3): 229-32.
14. McEniery CM, Yasmin, Wallace S, et al. Increased stroke volume and aortic stiffness contribute to isolate systolic hypertension in young adults. Hypertension 2005; 46: 221-6.
15. Pickering TG. Isolate systolic hypertension in the young. J Clin Hypertens 2004; 6(1): 47-8.
Review
For citations:
Milyagina I.V., Milyagin V.A., Grekova M.V., Kopteva V.V. Early vascular remodeling role in arterial hypertension pathogenesis among young patients. Cardiovascular Therapy and Prevention. 2006;5(4):14-21. (In Russ.)
Views:
687
Email this article 
