Hemorheological system in coronary heart disease patients: prognostic value
Abstract
Aim. To develop highly sensitive prognostic methods for coronary heart disease (CHD) and acute coronary event (ACE) risk stratification, on the basis of biophysical hemorheological system assessment.
Material and methods. Seven-year follow-up data on CHD patients were analyzed: re-hospitalization rate and reasons; main hemorheological parameters, their temporal and velocity characteristics; hemorheological system modeling by creating phase fragments in multi-dimensional phase space.
Results. Whole blood viscosity was significantly higher in patients with 3 or more ACE, comparing to ACE-free individuals or participants with <3 ACE. Velocity parameter dynamics correlated with ACE hospitalization rate. Phase fragment method demonstrated hemorheological system destabilization, maximal in patients with 3 or more ACE.
Conclusion. Prognostic value of whole blood viscosity and velocity assessment was demonstrated in CHD patients. Various CHD therapy algorithms, depending on hemorheological parameters and ACE risk, were developed.
About the Authors
L. I. Malinova
Saratov Research Institute of Cardiology, State Federal Agency for Health and Social Development, Saratov
Russian Federation
Russian Federation
P. Yu. Dovgalevsky
Saratov Research Institute of Cardiology, State Federal Agency for Health and Social Development, Saratov
Russian Federation
Russian Federation
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Review
For citations:
Malinova L.I., Dovgalevsky P.Yu. Hemorheological system in coronary heart disease patients: prognostic value. Cardiovascular Therapy and Prevention. 2007;6(3):19-24. (In Russ.)
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