СЕРДЦЕ И ВОЗРАСТ (ЧАСТЬ I): ТЕОРИИ СТАРЕНИЯ, МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ
https://doi.org/10.15829/1728-8800-2013-1-88-94
Аннотация
Старение сердца — сложный процесс, включающий множество клеточных и молекулярных изменений на клеточном и молекулярном уровнях и приводящих к формированию разных фенотипов старения внутри одного вида. Согласно теориям старения на молекулярно-генетическом уровне взаимодействуют несколько механизмов, включая соматические мутации, укорочение теломер, окислительный стресс и дефекты митохондрий. Наиболее признанные на сегодня теории старения, а также морфологические признаки старения сердца на клеточном, субклеточном и органном уровнях представлены в этой статье.
Об авторах
Д. У. Акашева
ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава России, Москва
Россия
с.н.с. отдела комплексного снижения риска неинфекционных заболеваний
Россия
с.н.с. отдела комплексного снижения риска неинфекционных заболеваний
И. Д. Стражеско
ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава России, Москва
Россия
в.н.с. отдела
Россия
в.н.с. отдела
Е. Н. Дудинская
ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава России, Москва
Россия
с.н.с. отдела
Россия
с.н.с. отдела
Е. В. Найденко
ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава России, Москва
Россия
аспирант
Россия
аспирант
О. Н. Ткачева
ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава России, Москва
Россия
Россия
руководитель отдела
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Рецензия
Для цитирования:
Акашева Д.У., Стражеско И.Д., Дудинская Е.Н., Найденко Е.В., Ткачева О.Н. СЕРДЦЕ И ВОЗРАСТ (ЧАСТЬ I): ТЕОРИИ СТАРЕНИЯ, МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ. Кардиоваскулярная терапия и профилактика. 2013;12(1):88-94. https://doi.org/10.15829/1728-8800-2013-1-88-94
For citation:
Akasheva D.U., Strazhesko I.D., Dudinskaya E.N., Naydenko E.V., Tkacheva O.N. HEART AND AGE (PART I): AGEING THEORIES AND MORPHOLOGICAL CHANGES. Cardiovascular Therapy and Prevention. 2013;12(1):88-94. (In Russ.) https://doi.org/10.15829/1728-8800-2013-1-88-94
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