Endothelial vasoactive mediators in young patients with minor heart anomalies
Abstract
Aim. To investigate regulatory vasoactive mediators – endothelin-1 (ET-1), 6-ketoprostaglandin F1α (6-keto-PGF1α), thromboxane В2 (TXВ2) – in young patients with minor heart anomalies (MHA) and non-differentiated connective tissue dysplasia (CTD).
Material and methods. Fifty-three patients, 37 men and 16 women (mean age 22,0±0,8 years) were examined. Plasma concentrations of ТХВ2, 6-keto-PGF1α and ET-1 were measured by immune-enzyme methods.
Results. Some specific features of vasoactive mediators in MHA were observed. In patients with three MHA, ET-1 level was increased. In Stage II mitral valve prolapse (MVP), combined with atopic chord (AC) and/or Stage II mitral regurgitation, TXB2 level was increased, without any significant thromboxane-prostacyclin dysbalance. In patients with mixomatous MV degeneration, plasma ET-1 concentration was increased, and TXB2 level was higher than that of 6-keto-PGF1α.
Conclusion. In MHA patients, functional endothelial status is disturbed. Disturbance severity is maximal in three MHA and mixomatous MV degeneration.
About the Authors
A. V. Yagoda
Stavropol State Medical Academy, Stavropol
Russian Federation
Russian Federation
N. N. Gladkikh
Stavropol State Medical Academy, Stavropol
Russian Federation
Russian Federation
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Review
For citations:
Yagoda A.V., Gladkikh N.N. Endothelial vasoactive mediators in young patients with minor heart anomalies. Cardiovascular Therapy and Prevention. 2007;6(3):56-60. (In Russ.)
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