HEART AND AGE (PART I): AGEING THEORIES AND MORPHOLOGICAL CHANGES
https://doi.org/10.15829/1728-8800-2013-1-88-94
Abstract
Heart ageing is a complex process including multiple cellular and molecular-level changes and resulting in different ageing phenotypes within the same biological species. According to the existing ageing theories, the multiple interacting mechanisms of ageing include somatic mutations, telomere shortening, oxidative stress, and mitochondrial defects. The review presents the most accepted ageing theories and discusses morphological characteristics of heart ageing on subcellular, cellular, and organ levels.
About the Authors
D. U. Akasheva
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
I. D. Strazhesko
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
E. N. Dudinskaya
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
E. V. Naydenko
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
O. N. Tkacheva
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
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For citations:
Akasheva D.U., Strazhesko I.D., Dudinskaya E.N., Naydenko E.V., Tkacheva O.N. HEART AND AGE (PART I): AGEING THEORIES AND MORPHOLOGICAL CHANGES. Cardiovascular Therapy and Prevention. 2013;12(1):88-94. (In Russ.) https://doi.org/10.15829/1728-8800-2013-1-88-94
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ISSN 2619-0125 (Online)
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