Antioxidant status and lipid peroxidation in stable coronary heart disease patients with dyslipidemia

Aim. To study lipid peroxidation (LP), pro-oxidant status, and antioxidant protection in coronary heart disease (CHD) patients with stable angina and post-infarction cardiosclerosis, who underwent coronaroangiography (CAG). Material and methods. The study included 32 CHD patients with Functional Class II-III angina, who underwent CAG, and 22 relatively healthy controls. Before CAG, plasma levels of lipids, PL products, uric acid, ceruloplasmin (CP), transferrin (RF) and methemoglobin (electron paramagnetic resonance), homocysteine (highly effective liquid chromatography), superoxide dismutase (SOD) and glutathione peroxidase (GP) in red blood cells were measured. Results. In CAG, severe coronary artery pathology was registered: occlusions of at least 70% comprised 63,7% of the total stenosis rate. Severe lipid metabolism and PL disturbances, as well as decrease in tissue and plasma antioxidant enzymes (SOD by 10%, GP by 46%, CP/TF by 33%) – were observed, comparing to the control group. There was a direct correlation between coronary artery stenosis rate and age (r=0,4) or levels of total cholesterol, low-density lipoprotein cholesterol (r=0,3), and PL product, MDA (r=0,34). Inverse correlation between stenosis number and antioxidant enzyme levels was also registered in CHD patients for SOD (r=-0,5), GP (r=-0,3), and CP/TF (r=-0,3). Conclusion. Coronary artery atherosclerosis severity was affected by tissue and plasma antioxidant enzyme levels, as well as by LP manifestation.

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