ADVANCE Study: in patients with Type 2 diabetes mellitus, antihypertensive therapy decreases cardiovascular risk inde pendently of baseline blood pressure
Abstract
Blood pressure (BP) level is an important determinant of micro- and macrovascular complication risk in patients with Type 2 diabetes mellitus (DM-2). One of the aims of ADVANCE Study was, therefore, to assess the effects of Fixed-dose perindopril and indapamide (Noliprel®) combination, added to standard therapy, on cardiovascular, renal and other complication risk in DM-2 individuals. The four-year study included 11140 DM-2 patients taking Noliprel ®/Noliprel® forte or placebo, together with previously administered standard treatment. Additional therapy with Noliprel® was associated with the reduction in systolic and diastolic BP levels – by 5,6 and 2,2 mm Hg, respectively. Relative risk of main micro - and macrovascular complications decreased by 9%, and the risks of cardiovascular death, all-cause death and renal complications – by 18%, 14%, and 21%, respectively.
About the Author
I. E. Chazova
Russian Cardiology Scientific and Clinical Complex, Federal Agency on High Medical Technologies. Moscow
Russian Federation
Russian Federation
References
1. Stamler J, Vaccaro O, Neaton JD, Wetworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16(2): 434-44.
2. Asia Pacific Cohort Studies Collaboration. Blood glucose and riskof cardiovascular disease in the Asia Pacific region. Diabetes care 2004; 27(3): 2836-42.
3. ADVANCE Collaborative Group. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with tupe 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. The Lancet < 2007 < published online September 2, 2007.
4. ADVANCE Collaborative Group. ADVANCE – Action in Diabetes and Vascular Disease: patient recruitment and characteristics of the study population at baseline. Diabetes Med 2005; 22(7): 882-8.
Review
For citations:
Chazova I.E. ADVANCE Study: in patients with Type 2 diabetes mellitus, antihypertensive therapy decreases cardiovascular risk inde pendently of baseline blood pressure. Cardiovascular Therapy and Prevention. 2008;7(2):5-10. (In Russ.)
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