Associations of mortality relative risk, smoking status, alcohol intake, and educational level in women
Abstract
The authors assess relative risk (RR) of coronary heart disease (CHD), stroke (S), cardiovascular disease (CVD), and total mortality, according to smoking status, alcohol intake, and educational level in women. In ex-smokers and current smokers, mortality RR was significantly and dose-dependently increased. In occasional and low-dose drinkers, RR of CVD, CHD, and total mortality was reduced. At the same time, in moderate drinkers, RR was similar to that in frequent and high-dose drinkers. Mortality RR was inversely linked to educational level: in highly educated women, RR was substantially lower than in participants with lower educational levels. The authors assess relative risk (RR) of coronary heart disease (CHD), stroke (S), cardiovascular disease (CVD), and total mortality, according to smoking status, alcohol intake, and educational level in women. In ex-smokers and current smokers, mortality RR was significantly and dose-dependently increased. In occasional and low-dose drinkers, RR of CVD, CHD, and total mortality was reduced. At the same time, in moderate drinkers, RR was similar to that in frequent and high-dose drinkers. Mortality RR was inversely linked to educational level: in highly educated women, RR was substantially lower than in participants with lower educational levels.
About the Authors
V. V. KonstantinovRussian Federation
S. A. Shalnova
Russian Federation
C. V. Kireev
Russian Federation
T. N. Timofeeva
Russian Federation
D. B. Shestov
Russian Federation
A. V. Kapustina
Russian Federation
Yu. A. Balanova
Russian Federation
I. N. Lel’chuk
Russian Federation
A. D. Deev
Russian Federation
References
1. Чазов Е.И. Итоги, задачи и перспективы развития кардиологии и кардиологической службы. Сов здравоохр 1982; 5: 3-10.
2. Оганов Р.Г. Факторы риска и профилактика сердечно-сосудистых заболеваний. Медицина 2003; 2: 10-5.
3. Шальнова С.А., Деев А.Д., Оганов Р.Г. Распространенность курения в России. Результаты обследования национальной представительной выборки населения. Проф забол укреп здор 1998; 3: 9-12.
4. Bottiger L. Alcohol and Diseases. Acta Med Scand 1988; 223: 97-9.
5. Константинов В.В., Жуковский Г.С., Деев А.Д. и др. Связь потребления алкоголя с факторами риска и смертностью от сердечно-сосудистых и других хронических неинфекционных заболеваний среди мужского населения. Кардиология 1998; 2: 29-36.
6. Klatsky AL, Friedman GD, Siegelaub AB. Alcohol use and cardiovascular disease: The Kaiser-Permanentte experience. Circulation 1981; 64(Suppl 3): 32-41.
7. Janszky I, Ljung R, Hallqvist J, et al. Karolinska Institutet, Stockholm, Sweden – Moderate prior alcohol consumption is associated with a more favourable long-term mortality after a first AMI, the SHEEP study. Всемирный конгресс кардиологов, Барселона-2006.
8. Совместное исследование СССР – США по распространенности дислипопротеидемий и ишемической болезни сердца в советской и американской популяции. Тер архив 1977; 4: 26-37.
9. Lipid Research Clinics Program. Manual of Laboratory Operations. Washington D.C. DHEW Publication N (NIH) 1974; 1: 75-628.
10. The Coronary Primari Prevention Trial. Design and Implementation. The Lipid Research Clinics Program. J Chron Dis 1979; 32: 609-31.
11. Константинов В.В., Жуковский Г.С., Тимофеева Т.Н. и др. Ишемическая болезнь сердца, факторы риска и смертность среди мужского населения в связи с уровнем образования. Кардиология 1996; 1: 37-41.
12. Шальнова С.А., Деев А.Д., Шестов Д.Б. и др. Прогностическая оценка эпидемиологических характеристик ишемической болезни сердца. Кардиология 1997; 9: 49-54.
13. SAS/STAT Users Guide, Version 6, Fourth Edition, Vol.1,2.SAS Institute Inc Cary NC USA 1990.
14. Willett WC, Green A, Stampfer MI, et al. Relative and absolute excess risk of Corionary Heart disease among women who smoke cigarettes. N Engl J 1991; 122: 438-47.
15. Howard G, Wagenknecht LE, Bruke GL, et al. Smoking and Progression of Atherosclerosis. JAMA 1998; 279: 119-24.
16. Lip GY, Blann AD, Jones AF, et al. Relation of Endothelium, Thrombogenesis, and Hemorheology in Systemic Hypertension to Ethnicity and Left Venricular Hypertrophy. Am J Cardiol 1997; 80: 1566-71.
17. IIgenli TF, Akpinar O, Acikalin A. Acute effects of smoking on right ventricular diastolic function: a tissue Doppler imaging study on healthy subjects. Всемирный конгресс кардиологов, Барселона-2006. Abstract.
18. Hosokawa S, HissaY, Ogura R, et al. Effects of smoking cessation on coronary endothelial function in patients with recent myocardial infarction. Всемирный конгресс кардиологов, Барселона-2006.
19. Bosetti C, Negri E, Tavani A, et al. Smoking and Acute Myocardial Infarction among women and men: A case-Control Study in Italy. Prev Med 1999; 29: 343-8.
20. Tverdal A, Thelle D, Stensvold T, et al. Mortality in ralation to smoking history: 13 years follow-up of 68 000 Norvegian men and women 35-49 years. J Clin Epidemiol 1993; 43: 475-87.
21. MONICA project: geographic variation. The major risk factors of CHD in men and women aged 33-66 years. WHO 1988; 41: 115.
22. Yusuf S, Hawken S, Ounpuu S, et al., on behalf of the INTER-HEART Study Investigators, 2004. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INRERHEART Study): case-control study, Published online September 3, 2004: 1-16.
23. Fuchs CS, Stampfer MJ, Colditz GA, et al. Alcohol consumption and mortality among women. N Engl J Med 1995; 332: 1245-50.
24. Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997; 337: 1705-14.
25. Nanchyahal K, Ashton WD, Wood DA. Alcohol consumption, metabolic cardiovascular risk factors and hypertension in women. Intern J Epidemiol 2000; 29: 57-64.
26. Hendriks HF, Veenstra J, Wierik V, et al. Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. Br Med J 1994; 308: 1003-6.
27. Ridker PM, Vanghan DE, Stampfer MJ, et al. Association of moderate alcohol consumption and plasma concentration of endogenous tissure-typen plasminogen activator. JAMA 1994; 272: 929-33.
28. Liu K, Cedres LB, Stamler J. Relashionship of education to major risk factors and death from CHD cardiovascular diseases all causes: findings of three Chicago epidemiologic studies. Circulation 1982; 667: 1308-14.
29. Dennis B, Zhukovsky G, Shestov D, et al. The association of Education with Coronary Heart Disease mortality in the U.S.S.R. Lipid Research Clinics Study. Intern J Epidemiol 1993; 22(3): 420-7.
30. Luepker RV, Rosamond W, Sporafka M, et al. Population trends in Coronary Heart Disease Risk, Associations with Education and Income. Circulation 1990; 81:2(Abstract 5).
Review
For citations:
Konstantinov V.V., Shalnova S.A., Kireev C.V., Timofeeva T.N., Shestov D.B., Kapustina A.V., Balanova Yu.A., Lel’chuk I.N., Deev A.D. Associations of mortality relative risk, smoking status, alcohol intake, and educational level in women. Cardiovascular Therapy and Prevention. 2007;6(3):100-105. (In Russ.)