Myocardial contractility and body mass index in patients with coronary heart disease and Type 2 diabetes mellitus
Abstract
Aim. To investigate left and right ventricular (LV, RV) myocardial contractility in patients with coronary heart disease (CHD), Type 2 diabetes mellitus (DM-2), and various body mass index (BMI) levels.
Material and methods. The study included 120 patients: 66 with CHD + DM-2 (Group I), and 54 with CHD only (Group II). All participants underwent standard clinical examination and balanced radioventriculography (BRVG).
Results. In CHD and DM-2 patients with normal LV ejection fraction, EF (>50%), regardless of obesity level, LV and RV diastolic dysfunction (decreased 1/3 diastolic filling) was observed, pointing to increased myocardial stiffness, compared with CHD individuals. In CHD, DM-2, and moderate obesity (IMT<29 kg/m2), hyperkinetic contractility type was registered. Obesity progression was associated with significant increases in LV and RV volumes among CHD and DM-2 participants. Moreover, obesity progression was linked to substantial reduction in LV and RV inotropic function (reduced 1/3 systolic LV and RV output, decreased RV EF).
Conclusion. In obesity progression, the most sensitive BRVG parameters were 1/3 systolic output, end-systolic and diastolic LV and RV volume, RV EF.
About the Authors
A. E. Vasilyeva
I.M. Sechenov Moscow Medical Academy, Moscow
Russian Federation
Russian Federation
Z. O. Georgadze
I.M. Sechenov Moscow Medical Academy, Moscow
Russian Federation
Russian Federation
V. A. Volodina
I.M. Sechenov Moscow Medical Academy, Moscow
Russian Federation
Russian Federation
T. S. Vargina
I.M. Sechenov Moscow Medical Academy, Moscow
Russian Federation
Russian Federation
I. G. Fomina
I.M. Sechenov Moscow Medical Academy, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Vasilyeva A.E., Georgadze Z.O., Volodina V.A., Vargina T.S., Fomina I.G. Myocardial contractility and body mass index in patients with coronary heart disease and Type 2 diabetes mellitus. Cardiovascular Therapy and Prevention. 2007;6(4):30-36. (In Russ.)
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