Carvedilol effectiveness in complex treatment of patients with arterial hypertension, coronary heart disease, and Type 2 diabetes mellitus
Abstract
Aim. To assess carvedilol effectiveness in patients with coronary heart disease (CHD) and arterial hypertension (AH), with or without associated diabetes mellitus (DM).
Material and methods. The study included 27 participants with mild to moderate AH and effort angina of various functional classes. Thirteen patients also had DM in anamnesis. Carvedilol was administered in initial dose of 6,25-12,5 mg/d. At baseline and in the end of the study, clinical status, blood biochemistry, and 24-hour ECG monitoring data were analyzed.
Results. In patients with or without DM, regular carvedilol therapy facilitated significant decrease in heart rate, blood pressure, microalbuminuria, frequency and duration of pain and silent ischemia episodes with various rhythm disturbances. Carvedilol therapy was not associated with substantial metabolic disturbances.
Conclusion. Carvedilol was effective in complex CHD and AH treatment among DM patients.
About the Authors
R. M. Shakirova
Kazan State Medical University, Kazan
Russian Federation
Russian Federation
A. S. Galyavich
Kazan State Medical University, Kazan
Russian Federation
Russian Federation
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Review
For citations:
Shakirova R.M., Galyavich A.S. Carvedilol effectiveness in complex treatment of patients with arterial hypertension, coronary heart disease, and Type 2 diabetes mellitus. Cardiovascular Therapy and Prevention. 2007;6(5):25-29. (In Russ.)
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