Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension
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Abstract
Aim. To analyze the association between tumor necrosis factor-alpha gene –308 G/A polymorphism and essential arterial hypertension (EAH).
Material and methods. The study included 354 EAH patients and 295 age-matched healthy subjects. DNA was extracted from venous blood. Genotyping was performed using polymerase chain reaction followed by restriction amplicon analysis.
Results. TNFA -308*G/*G genotype frequency was significantly lower among EAH patients with stroke than in control group (60,98% vs 78,98%; p=0,015). EAH patients with TNFA -308 *G/*G genotype had lower stroke risk (OR=0,38; 95% CI: 0,21-0,83).
Conclusion. The results obtained suggest that TNFA gene -308G/A polymorphism is involved in stroke pathogenesis among EAH patients.
About the Authors
Y. R. Timasheva
Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Science
Russian Federation
Russian Federation
T. R. Nasibullin
Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Science
Russian Federation
Russian Federation
A. N. Zakirova
Bashkir State Medical University, Ufa
Russian Federation
Russian Federation
O. E. Mustafina
Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Science
Russian Federation
Russian Federation
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Review
For citations:
Timasheva Y.R., Nasibullin T.R., Zakirova A.N., Mustafina O.E. Tumor necrosis factor alpha gene polymorphism in patients wiht essential hypertension. Cardiovascular Therapy and Prevention. 2007;6(6):5-9. (In Russ.)
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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)
ISSN 2619-0125 (Online)
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