Кандесартана цилексетил в превентивной терапии сердечно-сосудистых заболеваний
Аннотация
Эффективность и хорошая переносимость блокаторов ангиотензиновых рецепторов при артериальной гипертонии (АГ) доказаны в рандомизированных, широкомасштабных, клинических исследованиях. Установлены существенные фармакодинамические различия между препаратами, блокирующими ангиотензиновые рецепторы, что имеет потенциально важное клиническое значение. Доказано преимущество кандесартана по степени и длительности снижения артериального давления (АД) при АГ и уменьшение частоты сердечно-сосудистых осложнений при длительном лечении АГ кандесартаном. Благоприятное влияние кандесартана на метаболизм отмечено у пациентов с сахарным диабетом, независимо от антигипертензивного эффекта. В контролируемых исследованиях с применением кандесартана при хронической сердечной недостаточности полностью доказана их эффективность как в комплексной терапии при назначении кандесартана в комбинации с E-адреноблокатором, так и при дополнительном присоединении к комбинации E-адреноблокатора с ингибитором ангиотензин-превращающего фермента.
Об авторе
А. Я. Ивлева
ФГУ «Поликлиника №3» Управления делами Президента РФ, Москва
Россия
Тел./факс: (495) 680-71-65
Россия
Тел./факс: (495) 680-71-65
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Рецензия
Для цитирования:
Ивлева А.Я. Кандесартана цилексетил в превентивной терапии сердечно-сосудистых заболеваний. Кардиоваскулярная терапия и профилактика. 2007;6(6):83-90.
For citation:
Ivleva A.Ya. Candesartan cilexetil in cardiovascular prevention. Cardiovascular Therapy and Prevention. 2007;6(6):83-90. (In Russ.)
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