Insertion-deletion polymorphism of ACE gene and increased body mass among hypertensive patients from various ethnic groups in Mordovia Republic
Abstract
Aim.To stuffy the association between insertion-deletion (ID) polymorphism of ACE gene and increased body mass (BM) among patients with arterial hypertension (AH), representing various ethnic groups of Mordovia Republic.
Material and methods. In total, 295 patients with verified essential AH were examined: 207 Mordovians and 88 Russians. The control group included 221 people: 147 Mordovians and 74 Russians. In all participants, anamnestic, clinical, laboratory, and instrumental examination was performed, including 12-lead electrocardiography, echocardiography, and assessment of ACE gene ID polymorphism.
Results. It was demonstrated that higher BM index levels were registered in ID genotype carriers of either ethnicity more frequently, but not significantly.
Conclusion.In both Mordovian and Russian patients with AH, no significant association was observed between ACE gene polymorphism and increased MT.
About the Authors
L. N. Goncharova
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
D. V. Biryukova
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
Z. B. Khasanova
Russian Cardiology Scientific and Clinical Complex, Federal Agency on High Medical Technologies
Russian Federation
Russian Federation
Moscow
E. I. Timoshkina
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
O. N. Kuzovenkova
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
S. V. Semenova
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
V. A. Snegovskoy
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
L. K. Fedotkina
N.P. Ogarev Mordovian State University
Russian Federation
Russian Federation
Saransk
N. V. Konovalova
Russian Cardiology Scientific and Clinical Complex, Federal Agency on High Medical Technologies
Russian Federation
Russian Federation
Moscow
A. Yu. Postnov
Russian Cardiology Scientific and Clinical Complex, Federal Agency on High Medical Technologies
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Goncharova L.N., Biryukova D.V., Khasanova Z.B., Timoshkina E.I., Kuzovenkova O.N., Semenova S.V., Snegovskoy V.A., Fedotkina L.K., Konovalova N.V., Postnov A.Yu. Insertion-deletion polymorphism of ACE gene and increased body mass among hypertensive patients from various ethnic groups in Mordovia Republic. Cardiovascular Therapy and Prevention. 2009;8(6):5-9. (In Russ.)
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