Lipid-lowering effectiveness of a Russian generic of atorvastatin in patients with various hyperlipidaemia phenotypes
Abstract
Aim. To assess lipid-lowering effectiveness of generic atorvastatin in patients with various hyperlipidaemia (HLP) phenotypes in an open, short-term (four weeks) study.
Material and methods. All participants were divided into two groups — with isolated hypercholesterolemia (HCH) and normal fasting triglycerides, (n=25), and with combined HLP and TG levels >1,7 mmol/l (n=26). Atorvastain dose was 20 mg/d. Serum levels of total cholesterol (TCH), TG and high-density lipoprotein cholesterol (HDL- CH) were measured by standard enzyme methods. Medication effectiveness was assessed by the reduction in low- density lipoprotein CH (LDL-CH) and TG levels.
Results. In both groups, the medication significantly decreased serum levels of LDL-CH by 34-36,4%, without any substantial inter-group difference. However, lipid-lowering effect in patients with lower baseline TG levels was stronger than in individuals with normal TG concentrations — 27,1% and 12,9%, respectively (p=0,027).
Conclusion. Cholesterol-lowering effect of generic atorvastatin (20 mg/d) was similar in patients with IIa and IIb HL. The effect on TG levels depended on HLP phenotype and was greater in individuals with higher baseline TG levels.
About the Authors
P. P. Malyshev
L.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex
Russian Federation
Russian Federation
Moscow
T. A. Rozhkova
L.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex
Russian Federation
Russian Federation
Moscow
Z. Yu. Malmakova
L.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex
Russian Federation
Russian Federation
Moscow
V. V. Kukharchuk
L.A. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Malyshev P.P., Rozhkova T.A., Malmakova Z.Yu., Kukharchuk V.V. Lipid-lowering effectiveness of a Russian generic of atorvastatin in patients with various hyperlipidaemia phenotypes. Cardiovascular Therapy and Prevention. 2009;8(6):16-20. (In Russ.)
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