Phospholipid metabolism and effectiveness of a glycoprotein IIb/IIIa receptor blocker tirofiban in patients with acute coronary syndrome without ST segment elevation
Abstract
Aim. To study the effects of tirofiban, a glycoprotein IIb/IIIa receptor blocker, on platelet (PL) phospholipids (PhL) in patients with acute coronary syndrome (ACS).
Material and methods. The study included 55 ACS patients without ST segment elevation (↓ST), receiving standard therapy; 26 participants were administered tirofiban. The control group included 23 healthy volunteers, without any cardiovascular disease. In all participants, PL PhL characteristics were assessed at baseline, at Day 3 and Days 7-10.
Results. In ACS patients, both qualitative and quantitative changes in PL PhL metabolism were observed, which could result in disturbed PL hemostasis. The main manifestation of these disturbances was increased lysophosphatidyl choline (LFS) level in PL membranes. Disturbed PL PhL metabolism was observed in all ACS patients, being maximally manifested at baseline.
Conclusion. Tirofiban therapy, as a part of standard ACS↓ST treatment, improved PhL composition of PL membranes and beneficially affected PL hemostasis.
About the Authors
Sh. I. Makhamatova
Republican Research Centre for Emergency Medicine
Uzbekistan
Uzbekistan
Tashkent
M. L. Kenzhaev
Republican Research Centre for Emergency Medicine
Uzbekistan
Uzbekistan
Tashkent
B. A. Alyavi
Republican Research Centre for Emergency Medicine
Uzbekistan
Uzbekistan
Tashkent
Kh. A. Mamatkulov
Republican Research Centre for Emergency Medicine
Uzbekistan
Uzbekistan
Tashkent
L. Sh. Davlyatova
Republican Research Centre for Emergency Medicine
Uzbekistan
Uzbekistan
Tashkent
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Review
For citations:
Makhamatova Sh.I., Kenzhaev M.L., Alyavi B.A., Mamatkulov Kh.A., Davlyatova L.Sh. Phospholipid metabolism and effectiveness of a glycoprotein IIb/IIIa receptor blocker tirofiban in patients with acute coronary syndrome without ST segment elevation. Cardiovascular Therapy and Prevention. 2009;8(6):29-34. (In Russ.)
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