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Кардиоваскулярная терапия и профилактика

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Двойное ингибирование холестерина — новый подход к эффективному контролю гиперлипидемии и атеросклероза

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Аннотация

Повышение уровня холестерина липопротеринов низкой плотности (ХС ЛНП) — один из основных факторов риска (ФР) ишемической болезни сердца и атеросклероза. Статины, имея убедительную доказательную базу по снижению смертности, являются основными препаратами для лечения больных с ате­росклерозом. Результаты контролируемых исследований последних лет по снижению ХС послужили обоснованием для снижения уровня целевых значений липидов: ХС ЛНП ≤ 2 ммоль/л. Двойное ингибирование ХС — новая концепция в снижении ХС плазмы крови до 50% за счет блокирования синтеза (статин) и уменьшения реабсорбции пищевого и билиарного ХС в тонком кишечнике. Клинические исследования препарата Инеджи® с фиксированной комбинацией (эзетимиб/симвастатин) показали высокую эффективность в достижении новых целевых уровней ХС ЛНП, а также хорошую переносимость и безопасность по сравнению с монотерапией статинами. Текущее клиническое исследование IMPROVE—IT с оценкой влияния двойного ингибирования на сердечно-сосудистую смертность позволит окончательно определить место эзетимиба и Инеджи® в лечении больных с дислипидемиями и атеросклерозом.

Об авторах

А. В. Сусеков
Институт клинической кардиологии им А.Л. Мясникова ФГУ “РКНПК Росмедтехнологии”
Россия

Старший научный сотрудник отдела возрастных проблем сердечно-сосудистых заболеваний.

Москва, тел.: (495) 414-69-92



Н. Б. Горнякова
Институт клинической кардиологии им А.Л. Мясникова ФГУ “РКНПК Росмедтехнологии”
Россия

Младший научный сотрудник отдела.

Москва



М. Ю. Зубарева
Институт клинической кардиологии им А.Л. Мясникова ФГУ “РКНПК Росмедтехнологии”
Россия

Младший научный сотрудник отдела.

Москва



Т. А. Рожкова
Институт клинической кардиологии им А.Л. Мясникова ФГУ “РКНПК Росмедтехнологии”
Россия

Научный сотрудник отдела.

Москва



Е. Ю. Соловьева
Институт клинической кардиологии им А.Л. Мясникова ФГУ “РКНПК Росмедтехнологии”
Россия

Научный сотрудник отдела.

Москва



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Для цитирования:


Сусеков А.В., Горнякова Н.Б., Зубарева М.Ю., Рожкова Т.А., Соловьева Е.Ю. Двойное ингибирование холестерина — новый подход к эффективному контролю гиперлипидемии и атеросклероза. Кардиоваскулярная терапия и профилактика. 2009;8(6):98-110.

For citation:


Susekov A.V., Gornyakova N.B., Zubareva M.Y., Rozhkova T.A., Solovyeva E.Y. Double cholesterol inhibition — a new approach to effective control of hyperlipidemia and atherosclerosis. Cardiovascular Therapy and Prevention. 2009;8(6):98-110. (In Russ.)

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