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Кардиоваскулярная терапия и профилактика

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Статины и их антиаритмическая активность

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Аннотация

Клинические испытания используемых в настоящее время антиаритмических препаратов нередко свидетельствуют об их неэффективности при развитии жизнеугрожающих желудочковых аритмий и внезапной коронарной смерти (ВКС), а также о недостаточном фармакологическом контроле фибрилляции предсердий (ФП). Статины обладают помимо холестерин-снижающего действия рядом плейотропных эффектов (противовоспалительный, антипролиферативный, улучшение эндотелиальной функции и т.п.). Они способны снизить риск развития жизнеугрожающих аритмий и ВКС у больных острым инфарктом миокарда, перенесших коронарную реваскуляризацию и с наличием имплантированного кардиовертера-дефибриллятора. Терапия статинами способна уменьшить риск возникновения рецидивов ФП.

Об авторах

Н. Ш. Загидуллин
Башкирский государственный медицинский университет, Уфа
Россия
Тел.: +7 962-546-76-22


G. Michels
III Кельнская университетская клиника, Кельн
Германия
Тел.: +7 962-546-76-22


Ш. З. Загидуллин
Башкирский государственный медицинский университет, Уфа
Россия
Тел.: +7 962-546-76-22


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Для цитирования:


Загидуллин Н.Ш., Michels G., Загидуллин Ш.З. Статины и их антиаритмическая активность. Кардиоваскулярная терапия и профилактика. 2007;6(8):116-121.

For citation:


Zagidullin N.S., Michels G., Zagidullin S.Z. Statins and their antiarrhythmic activity. Cardiovascular Therapy and Prevention. 2007;6(8):116-121. (In Russ.)

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