Antiplatelet medications in acute coronary syndromes and percutaneous coronary interventions: focus on tirofiban
Abstract
The review presents literature data on the key role of platelet aggregation (PA) for intracoronary thrombogenesis in various acute coronary syndromes (ACS) and percutaneous coronary interventions (PCI). Clinical pharmacology of main antiplatelet medication (APM) classes is discussed, with emphasis on a new APM class - blockers (inhibitors) of IIb/IIIa glycoprotein receptors (GP IIb/IIIa). The authors analyse the results of randomized clinical trials on effectiveness and safety of abciximab, tirofiban, and eptifibatide in non-ST ACS and planned or urgent PCI. Clinical situations and other factors determining the choice of specific GP IIb/IIIa blocker are discussed.
About the Authors
T. A. Batyraliev
Sani Konukogly Medical Center. Gaziantep
Turkey
Turkey
D. V. Preobrazhensky
Educational and Research Medical Center, RF President Administration. Moscow
Russian Federation
Russian Federation
D. V. Fetzer
Sani Konukogly Medical Center. Gaziantep
Turkey
Turkey
B. A. Sidorenko
Educational and Research Medical Center, RF President Administration. Moscow
Russian Federation
Russian Federation
S. A. Pataraya
Educational and Research Medical Center, RF President Administration. Moscow
Russian Federation
Russian Federation
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Review
For citations:
Batyraliev T.A., Preobrazhensky D.V., Fetzer D.V., Sidorenko B.A., Pataraya S.A. Antiplatelet medications in acute coronary syndromes and percutaneous coronary interventions: focus on tirofiban. Cardiovascular Therapy and Prevention. 2008;7(6):79-88. (In Russ.)
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