Intima- media thickness of соmmоn carotid artery in patients with arterial hypertension and present or absent metabolic syndrome
Abstract
Aim: To study changes in intima-media thickness of common carotid artery (CCA IMT) in patients with arterial hypertension (AH) and present or absent metabolic syndrome (MS).
Material and methods: The study included 303 patients with Stage I-III AH and MS, aged 25-70 years (mean age 52 ± 18 years); 110 men and 193 women. All patients were divided into 2 groups (AH+MS and АН-MS) by MS presence or absence, respectively. The groups were comparable by sex and age distribution. Pach group was also divided into three subgroups by AH stage (I-III). Pipid profile assessment, 24-hour blood pressure monitoring (BPM) and carotid artery ultrasound were performed in all patients.
Results: CCA IMT was similar in participants with Stage I-II AH with or without MS. In Stage III AH, it was significantly higher among those with AH and MS, comparing to MS-free hypertensive individuals: 0,99+0,15 vs. 0,79+0,11 mm, respectively (p<0.05). AH duration correlated with mean CCA IMT (r=0,41, p<0.001), and IMT correlated with total cholesterol level in Stage III AH patients (r=0,42, p<0.01), low-density lipoprotein cholesterol (r=0,34, p<0,01), waist circumference (r=0,31, p<0.05), and blood glucose levels (r=0.29, p<0,01).
Conclusion. In AH patients, CCA IMT was associated with Stage III AH, MS, age, AH duration, systolic and pulse BP levels.
About the Authors
G. Kh. Sharipova
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex. Moscow
Russian Federation
Russian Federation
M. A. Saidova
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex. Moscow
Russian Federation
Russian Federation
V. B. Mychka
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex. Moscow
Russian Federation
Russian Federation
T. V. Balakhonova
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex. Moscow
Russian Federation
Russian Federation
O. N. Vorobyeva
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex. Moscow
Russian Federation
Russian Federation
I. E. Chazova
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex. Moscow
Russian Federation
Russian Federation
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Review
For citations:
Sharipova G.Kh., Saidova M.A., Mychka V.B., Balakhonova T.V., Vorobyeva O.N., Chazova I.E. Intima- media thickness of соmmоn carotid artery in patients with arterial hypertension and present or absent metabolic syndrome. Cardiovascular Therapy and Prevention. 2008;7(7):45-50. (In Russ.)
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