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Кардиоваскулярная терапия и профилактика

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Роль кавеол и кавеолинов в норме и патологии

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Аннотация

Открытые более 50 лет назад, кавеолы долгое время оставались загадочными плазмолеммными органеллами. Их описывали в виде обнаруживаемых при электронной микроскопии 50-100 нм инвагинации плазматической мембраны. Позже были открыты белки, названные кавеолинами, которые являются обязательным структурным компонентом мембран кавеол. С этого времени в многочисленных исследованиях была продемонстрирована их важная роль в различных функциях клетки, включая процессы эндоцитоза, гомеостаза липидов, сигнальную трансдукцию и онкосуппрессию. Выведение кавеолиндефицитных мышей позволило анализировать функции кавеол и кавеолинов в отношении физиологии человека. Действительно, накапливаются доказательства вовлечения кавеолинов в патогенез заболеваний человека, включая рак, мышечные дистрофии и сахарный диабет 2 типа. В обзоре описана роль кавеолинов в норме и патологии

Об авторах

Р. И. Воробьев
Алтайский государственный медицинский университет, г. Барнаул
Россия


Г. И. Шумахер
Алтайский государственный медицинский университет, г. Барнаул
Россия


М. А. Хорева
Алтайский государственный медицинский университет, г. Барнаул
Россия


И. В. Осипова
Алтайский государственный медицинский университет, г. Барнаул
Россия


Ю. В. Кореновский
Алтайский государственный медицинский университет, г. Барнаул
Россия


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Для цитирования:


Воробьев Р.И., Шумахер Г.И., Хорева М.А., Осипова И.В., Кореновский Ю.В. Роль кавеол и кавеолинов в норме и патологии. Кардиоваскулярная терапия и профилактика. 2008;7(8):105-111.

For citation:


Voroblev R.I., Shumakher G.I., Khoreva M.A., Osipova I.V., Korenovsky Y.V. Caveolae and caveolins role in health and disease. Cardiovascular Therapy and Prevention. 2008;7(8):105-111. (In Russ.)

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