Роль вазодилатирующих β-адреноблокаторов в контроле артериальной гипертензии и снижении риска сердечнососудистых и цереброваскулярных осложнений
https://doi.org/10.15829/1728-8800-2011-3-97-102
Аннотация
На протяжении нескольких десятилетий β-адреноблокаторы (β-АБ) продолжают играть ключевую роль в терапии артериальной гипертензии (АГ) и связанных с ней сердечно-сосудистых заболеваний (ССЗ). Согласно современным национальным рекомендациям, эти препараты остаются основой антигипертензивной терапии. По последним данным, терапия β-АБ ассоциируется с менее выраженным снижением общей смертности, смертности от ССЗ и частоты сердечно-сосудистых событий, по сравнению с лечением ингибиторами ренин-ангиотензиновой системы или антагонистами кальция. Следует отметить, что класс β-АБ включает в себя широкий спектр препаратов, и опасения о соотношении риска и пользы при приеме этих лекарственных средств могут не распространяться на вазодилатирующие β-АБ последнего поколения, такие как карведилол и небиволол. Постоянно растет число исследований, подтверждающих клиническую эффективность и безопасность вазодилатирующих β-АБ при АГ. Согласно результатам исследований конечных точек, эти препараты могут играть важную роль в снижении суммарного риска ССЗ у пациентов с сердечной недостаточностью — гипертензивного либо ишемического генеза.
Ключевые слова
β-адреноблокаторы,
эффективность,
гипертензия,
небиволол,
переносимость,
вазодилатирующие β-адреноблокаторы
Об авторе
Я. Н. Базиль
Программа сердечно-сосудистого здоровья Seinsheimer, Медицинский университет Южной Каролины и медицинский центр Ralph H. Johnson VA
Соединённые Штаты Америки
Чарлестон, Южная Каролина
Соединённые Штаты Америки
Чарлестон, Южная Каролина
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Рецензия
Для цитирования:
Базиль Я.Н. Роль вазодилатирующих β-адреноблокаторов в контроле артериальной гипертензии и снижении риска сердечнососудистых и цереброваскулярных осложнений. Кардиоваскулярная терапия и профилактика. 2011;10(3):97-102. https://doi.org/10.15829/1728-8800-2011-3-97-102
For citation:
Basile J.N. The role of vasodilating β-blockers in controlling arterial hypertension as a means of reducing cardiovascular and stroke risk. Cardiovascular Therapy and Prevention. 2011;10(3):97-102. (In Russ.) https://doi.org/10.15829/1728-8800-2011-3-97-102
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