Preview

Кардиоваскулярная терапия и профилактика

Расширенный поиск

Современные возможности ультразвуковых методов оценки атеросклеротического процесса у больных семейной гиперхолестеринемией

Полный текст:

Аннотация

Семейная гиперхолестеринемия (СГХС) — заболевание, сопровождающееся ранним развитием и быстрым прогрессированием атеросклероза. Учитывая, что распространенность СГХС в России растет, изучение методов диагностики атеросклероза у больных СГХС особенно актуально. Ультразвуковой метод исследования артерий — информативный, доступный, безопасный для оценки атеросклеротических изменений. В настоящее время имеющиеся методы ультразвукового исследования сосудов позволяют всесторонне описать стенку сосуда: дать структурную (качественную и количественную) и функциональную характеристики. Большая часть ультразвуковых параметров состояния артериальной стенки еще не нашла широкого применения в клинической практике, либо используется преимущественно в научных целях, либо находится на стадии разработки. Наиболее перспективными для применения в клинической практике у больных СГХС представляются маркеры, характеризующие одновременно степень выраженности и распространенности атеросклеротического процесса, такие как суммарная высота бляшек, лодыжечно-плечевой индекс, количество бляшек.

Об авторах

А. И. Ершова
ФГУ “Российский кардиологический научно-производственный комплекс” Министерства здравоохранения и социального развития Российской Федерации
Россия

аспирант, лаборант-исследователь лаборатории ультразвуковых методов исследования сосудов

Москва, Тел.: 8(495) 414-65-96, 8 (916) 559-85-36



А. Н. Мешков
ФГУ “Российский кардиологический научно-производственный комплекс” Министерства здравоохранения и социального развития Российской Федерации
Россия

научный сотрудник отдела возрастных проблем сердечно-сосудистых заболеваний

Москва



С. А. Бойцов
ФГУ “Российский кардиологический научно-производственный комплекс” Министерства здравоохранения и социального развития Российской Федерации
Россия

руководитель отдела возрастных проблем сердечно-сосудистых заболеваний

Москва



Т. В. Балахонова
ФГУ “Российский кардиологический научно-производственный комплекс” Министерства здравоохранения и социального развития Российской Федерации
Россия

ведущий научный сотрудник отдела новых методов диагностики, руководитель лаборатории ультразвуковых методов исследования сосудов

Москва



Список литературы

1. Балахонова Т.В. Ультразвуковая диагностика атеросклероза. Руководство по атеросклерозу и ишемической болезни сердца. Под ред. Акад. Е.И. Чазова, член-корр. РАМН В.В. Кухарчика, проф. С.А. Бойцова. М.: Медиа Медика 2007; 736 с (159-75).

2. Рогоза А.Н., Балахонова Т.В., Чихладзе Н.М. и др. Современные методы оценки состояния сосудов у больных артериальной гипертонией. М.: Издательский дом “Атмосфера” 2008; 72 с.

3. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации IV пересмотра. ВНОК. Москва 2009.

4. Al-Shali K, House AA, Hanley AJ, et al. Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions. Atherosclerosis 2005; 178(2): 319-25.

5. Atkov OY, Balahonova TV, Pogorelova OA. Non-invasive ultrasound detection of endothelial dysfunction. Eur J Ultrasound 1998; 7(1): 37-45.

6. Barnett PA, Spence JD, Manuck SB, Jennings JR. Psychological stress and the progression of carotid artery disease. J Hypertens 1997; 15(1): 49-55.

7. Belcaro G, Barsotti A, Nicolaides AN. “Ultrasonic biopsy”--a non-invasive screening technique to evaluate the cardiovascular risk and to follow up the progression and the regression of arteriosclerosis. Vasa 1991; 20(1): 40-50.

8. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 7; 340 (8828): 1111-5.

9. Chan SY, Mancini GB, Kuramoto L, et al. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. JACC 2003; 42(6): 1037-43.

10. Chimowitz MI, Weiss DG, Cohen SL, et al. Cardiac prognosis of patients with carotid stenosis and no history of coronary artery disease. Veterans Affairs Cooperative Study Group 167. Stroke 1994; 25(4): 759-65.

11. Cobble M, Bale B. Carotid intima-media thickness: knowledge and application to everyday practice. Postgrad Med 2010; 122(1): 10-8.

12. de Groot E, Hovingh GK, Wiegman A, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 2004; 109(23 Suppl 1): III33-8.

13. Deanfield J, Donald A, Ferri C, et al. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005; 23(1): 7-17.

14. Ellis SM, Naoumova RP, Neuwirth CK, et al. Measurement of the reflectivity of the intima-medial layer of the common carotid artery improves the discriminatory value of intima-medial thickness measurement as a predictor of risk of atherosclerotic disease. Ultrasound Med Biol 2007; 33(7): 1029-38. Epub 2007 Apr 19.

15. Ellis SM, Sidhu PS. Granularity of the carotid artery intimamedial layer: reproducibility of quantification by a computerbased program. Br J Radiol 2000; 73(870): 595-600.

16. Espeland MA, O’leary DH, Terry JG, et al. Carotid intimalmedia thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors. Curr Control Trials Cardiovasc Med 2005; 6(1): 3.

17. Finn AV, Kolodgie FD, Virmani R. Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology. Arterioscler Thromb Vasc Biol 2010; 30(2): 177-81. Epub 2009 Aug 13.

18. Fosse E, Johnsen SH, Stensland-Bugge E, et al. Repeated visual and computer-assisted carotid plaque characterization in a longitudinal population-based ultrasound study: the Troms² study. Ultrasound Med Biol 2006; 32(1): 3-11.

19. Grоnholdt ML, Nordestgaard BG, Wiebe BM, et al. Echolucency of computerized ultrasound images of carotid atherosclerotic plaques are associated with increased levels of triglyceride-rich lipoproteins as well as increased plaque lipid content. Circulation 1998; 97(1): 34-40.

20. Handa N, Matsumoto M, Maeda H, et al. Ultrasonic evaluation of early carotid atherosclerosis. Stroke 1990; 21(11): 1567-72.

21. Heliopoulos J, Vadikolias K, Mitsias P, et al. A three-dimensional ultrasonographic quantitative analysis of non-ulcerated carotid plaque morphology in symptomatic and asymptomatic carotid stenosis. Atherosclerosis 2008; 198(1):129-35. Epub 2008 Jan 24.

22. Hirai T, Sasayama S, Kawasaki T, Yagi S. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 1989; 80(1): 78-86.

23. Johnsen SH, Mathiesen EB, Joakimsen O, et al. Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Troms² Study. Stroke 2007; 38(11): 2873-80. Epub 2007 Sep 27.

24. Junyent M, Gilabert R, Jarauta E, et al. Impact of low-density lipoprotein receptor mutational class on carotid atherosclerosis in patients with familial hypercholesterolemia. Atherosclerosis 2010; 208(2): 437-41. Epub 2009 Aug 8.

25. Junyent M, Gilabert R, Zamb²n D, et al. Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defect. Arterioscler Thromb Vasc Biol 2008; 28(3): 580-6. Epub 2007 Dec 20.

26. Kastelein JJ, Akdim F, Stroes ES, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008; 358(14): 1431-43. Epub 2008 Mar 30.

27. Kastelein JJ, van Leuven SI, Burgess L, et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007; 356(16): 1620-30. Epub 2007 Mar 26.

28. Kroon AA,Ajubi N,van Asten WN,Stalenhoef AF. The prevalence of peripheral vascular disease in familial hypercholesterolaemia. J Intern Med 1995; 238(5): 451-9.

29. Lamina C, Meisinger C, Heid IM, et al. Association of anklebrachial index and plaques in the carotid and femoral arteries with cardiovascular events and total mortality in a populationbased study with 13 years of follow-up. Eur Heart J 2006; 27(21): 2580-7.

30. Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27(21): 2588-605. Epub 2006 Sep 25.

31. Leng GC, Papacosta O, Whincup P, et al. Femoral atherosclerosis in an older British population: prevalence and risk factors. Atherosclerosis 2000; 152(1): 167-74.

32. Lorenz MW, Bickel H, Bots ML, et al. Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project. Am Heart J 2010; 159(5): 730-6.e2.

33. Lorenz MW, Markus HS, Bots ML, et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007; 115(4): 459-67.

34. Masoura C, Pitsavos C, Aznaouridis K, et al. Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis. Atherosclerosis 2010.

35. Meuwese MC, de Groot E, Duivenvoorden R, et al. ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial. JAMA 2009; 301(11): 1131-9.

36. Morito N, Inoue Y, Urata M, et al. Increased carotid artery plaque score is an independent predictor of the presence and severity of coronary artery disease. J Cardiol 2008; 51(1): 25-32.

37. Nagai Y, Kitagawa K, Sakaguchi M, et al. Significance of earlier carotid atherosclerosis for stroke subtypes. Stroke 2001; 32(8): 1780-5.

38. Papamichael CM, Lekakis JP, Stamatelopoulos KS, et al. Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease. Am J Cardiol 2000; 86(6): 615-8.

39. Pollex RL, Hegele R. Genetic determinants of carotid ultrasound traits. Curr Atheroscler Rep 2006; 8(3): 206-15.

40. Riggio S, Mandraffino G, Sardo MA, et al. Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children. Eur J Clin Invest 2010; 40(3): 250-7.

41. Sakaguchi M, Kitagawa K, Nagai Y, et al. Equivalence of plaque score and intima-media thickness of carotid ultrasonography for predicting severe coronary artery lesion. Ultrasound Med Biol 2003; 29(3): 367-71.

42. Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 1991; 11(5): 1245-9.

43. Sandrock M, Cheng DC, Schmitz D, Schmidt-Trucks²ss A. Quantification of the wall inhomogeneity in B-mode sonographic images of the carotid artery. J Ultrasound Med 2002; 21(12): 1395-404.

44. Sidhu PS, Naoumova RP, Maher VM, et al. The extracranial carotid artery in familial hypercholesterolaemia: relationship of intimal-medial thickness and plaque morphology with plasma lipids and coronary heart disease. J Cardiovasc Risk 1996; 3(1): 61-7.

45. Simon A, Megnien JL, Chironi G. The value of carotid intimamedia thickness for predicting cardiovascular risk. Arterioscler Thromb Vasc Biol 2010; 30(2): 182-5. Epub 2009 Nov 30.

46. Simons LA, Sullivan D, Simons J, Celermajer DS. Effects of atorvastatin monotherapy and simvastatin plus cholestyramine on arterial endothelial function in patients with severe primary hypercholesterolaemia. Atherosclerosis 1998; 137(1): 197-203.

47. Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet 1969; 2(7635): 1380-2.

48. Smilde TJ, van den Berkmortel FW, Wollersheim H, et al. The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. Eur J Clin Invest 2000; 30(6): 473-80.

49. Smilde TJ, van Wissen S, Wollersheim H, et al. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 2001; 357(9256): 577-81.

50. Solberg LA,Eggen DA. Localization and sequence of development of atherosclerotic lesions in the carotid and vertebral arteries. Circulation 1971; 43(5): 711-24.

51. Spence JD, Eliasziw M, DiCicco M, et al. Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy. Stroke 2002; 33(12): 2916-22.

52. Spence JD, Hegele RA. Non-invasive assessment of atherosclerosis risk. Curr Drug Targets Cardiovasc Haematol Disord 2004; 4(2): 125-8.

53. Spence JD, Hegele RA. Noninvasive phenotypes of atherosclerosis: similar windows but different views. Stroke 2004; 35(3): 649-53. Epub 2004 Feb 12.

54. Spence JD. Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies. Int J Stroke 2006; 1(4): 216-21.

55. Spence JD. Ultrasound measurement of carotid plaque as a surrogate outcome for coronary artery disease. Am J Cardiol 2002; 89(4A): 10B-15B; discussion 15B-6.

56. Stein JH, Korcarz CE, Hurst RT, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008; 21(2): 93-111.

57. St²rk S, van den Beld AW, von Schacky C, et al. Carotid artery plaque burden, stiffness, and mortality risk in elderly men: a prospective, population-based cohort study. Circulation 2004; 110(3): 344-8. Epub 2004 Jul 6.

58. Takiuchi S, Kamide K, Miwa Y, et al. Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens 2004; 18(1): 17-23.

59. Tegos TJ, Kalomiris KJ, Sabetai MM, et al. Significance of sonographic tissue and surface characteristics of carotid plaques. AJNR Am J Neuroradiol 2001; 22(8): 1605-12.

60. Urbina EM, Williams RV, Alpert BS, et al. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension 2009; 54(5): 919-50. Epub 2009 Sep 3.

61. Vergeer M., Zhou R., Bots M.L. et al. Carotid atherosclerosis progression in familial hypercholesterolemia patients: a pooled analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE studies. Circ Cardiovasc Imaging. 2010 Jul 1;3(4):398-404. Epub 2010 May 21.

62. Verhamme P, Kerkhof F, Buysschaert I, et al. Carotid intimamedia thickness: more than a research tool? Acta Cardiol 2010; 65(1): 59-66.

63. Wendelhag I, Wiklund O, Wikstrand J. On quantifying plaque size and intima-media thickness in carotid and femoral arteries. Comments on results from a prospective ultrasound study in patients with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 1996; 16(7): 843-50.

64. Wiegman A, de Groot E, Hutten BA, et al. Arterial intimamedia thickness in children heterozygous for familial hypercholesterolaemia. Lancet 2004; 363(9406): 369-70.

65. Wittekoek ME, de Groot E, Prins MH, et al. Differences in intima-media thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease. Atherosclerosis 1999; 146(2): 271-9.

66. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005; 25(5): 932-43. Epub 2005 Feb 24.


Для цитирования:


Ершова А.И., Мешков А.Н., Бойцов С.А., Балахонова Т.В. Современные возможности ультразвуковых методов оценки атеросклеротического процесса у больных семейной гиперхолестеринемией. Кардиоваскулярная терапия и профилактика. 2011;10(3):113-122.

For citation:


Ershova A.I., Meshkov A.N., Boytsov S.A., Balakhonova T.V. Modern ultrasound methods and atherosclerosis assessment in patients with familial hypercholesterolemia. Cardiovascular Therapy and Prevention. 2011;10(3):113-122. (In Russ.)

Просмотров: 29


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)