Early predictors of metabolic syndrome in overweight children with upper digestive tract pathology
Abstract
Aim. To study early predictors of metabolic syndrome (MS) in 10-15-year-old children (n=200) with upper digestive tract pathology, in regard to their body mass (BM).
Material and methods. The main group (MG) included 127 children (46 girls, 81 boys) with increased BM. The control group (CG) consisted of 73 children (29 girls, 44 boys) with normal BM. Fasting serum levels of lipids, glucose, insulin, leptin, adiponectin, and final stable NO metabolites were measured.
Results. Compared to children with normal BM, overweight children had significantly higher prevalence of insulin resistance and hyperinsulinemia, as well as higher leptin levels and increased ratio of serum leptin/adiponectin. No atherogenic changes in lipid profile or NO metabolite concentrations were observed. The results obtained pointed to potential reversibility of MS in children.
Conclusion. Active treatment and prevention, aimed at diet and lifestyle modification, could normalize BM and reduce the risk of atherogenic metabolic disturbances in children with upper digestive tract pathology.
About the Authors
M. I. Dubrovskaya
Russian State Medical University
Russian Federation
Russian Federation
Moscow
Yu. G. Mukhina
Russian State Medical University
Russian Federation
Russian Federation
Moscow
N. N. Gumanova
State Research Centre for Preventive Medicine, Federal Agency on High Medical Technologies
Russian Federation
Russian Federation
Moscow
A. M. Olferyev
State Research Centre for Preventive Medicine, Federal Agency on High Medical Technologies
Russian Federation
Russian Federation
Moscow
V. A. Metelskaya
State Research Centre for Preventive Medicine, Federal Agency on High Medical Technologies
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Dubrovskaya M.I., Mukhina Yu.G., Gumanova N.N., Olferyev A.M., Metelskaya V.A. Early predictors of metabolic syndrome in overweight children with upper digestive tract pathology. Cardiovascular Therapy and Prevention. 2009;8(5):50-56. (In Russ.)
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