Functional characteristics of microcirculation and their prognostic value in patients with arterial hypertension
https://doi.org/10.15829/1728-8800-2011-5-14-19
Abstract
Aim. To study functional characteristics of microcirculation (MC), various hemodynamic variants of peripheral hemocirculation, and their clinical and prognostic value in patients with arterial hypertension (AH).
Material and methods. The study included 78 AH patients (mostly with Stage II-III AH) and 29 healthy individuals. Forearm skin MC was assessed by laser Doppler flowmetry.
Results. In AH patients, substantially elevated pre-capillary tone resulted in reduced nutritive blood flow, increased total peripheral vascular resistance, arteriolovenular shunting, and venous hyperemia. The depression of the main MC regulatory mechanisms was partly compensated by passive, breath and pulse-related factors.
Conclusion. Among all hemodynamic MC types, the negative effects on target organs and prognosis were maximal for spastic and congestive-stasic MC variants. MC types should be taken into account when choosing optimal strategy of pharmaceutical treatment.
About the Authors
A. P. Vasilyev
Tumen Cardiology Centre, Tomsk Research Institute of Cardiology Branch, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Tumen
Russian Federation
Tumen
N. N. Streltsova
Tumen Cardiology Centre, Tomsk Research Institute of Cardiology Branch, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Tumen
Russian Federation
Tumen
M. A. Sekisova
Tumen Cardiology Centre, Tomsk Research Institute of Cardiology Branch, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Tumen
Russian Federation
Tumen
M. V. Malishevskyi
Tumen State Medical Academy
Russian Federation
Tumen
Russian Federation
Tumen
I. V. Samoylova
West Siberian Medical Centre
Russian Federation
Tumen
Russian Federation
Tumen
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Review
For citations:
Vasilyev A.P., Streltsova N.N., Sekisova M.A., Malishevskyi M.V., Samoylova I.V. Functional characteristics of microcirculation and their prognostic value in patients with arterial hypertension. Cardiovascular Therapy and Prevention. 2011;10(5):14-19. (In Russ.) https://doi.org/10.15829/1728-8800-2011-5-14-19
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