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Кардиоваскулярная терапия и профилактика

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Роль вазодилатирующих β-адреноблокаторов в терапии пациентов с осложненной гипертензией: фокус на небиволол

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Аннотация

Несмотря на доказанную эффективность β-адреноблокаторов (β-АБ) в снижении риска заболеваемости и смертности, их применение у пациентов с сопутствующей сердечно-сосудистой патологией остается ограниченным. Недостаточно частое назначение β-АБ может быть связано с опасениями, основанными на плохой переносимости старых представителей этого класса препаратов. β-АБ с вазодилатирующими свойствами, такие как карведилол и небиволол, обладают лучшей переносимостью и не вызывают неблагоприятные метаболические эффекты, в отличие от традиционных β-АБ. Поскольку эндотелиальная дисфункция как ведущая патофизиологическая характеристика артериальной гипертензии (АГ) сильнее выражена в клинических популяциях, плохо реагирующих на терапию АГ (например, у пожилых и пациентов афро-американского происхождения), вазодилатирующие β-АБ могут стать наиболее показанными препаратами при лечении таких больных.



Об авторе

Т. Д. Жиль
Отделение медицины, медицинская школа Университета Тулана
Соединённые Штаты Америки

Новый Орлеан



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Для цитирования:


Жиль Т.Д. Роль вазодилатирующих β-адреноблокаторов в терапии пациентов с осложненной гипертензией: фокус на небиволол. Кардиоваскулярная терапия и профилактика. 2011;10(6):94-98.

For citation:


Giles T.D. The role of vasodilating β-blockers in patients with complicated hypertension: focus on nebivolol. Cardiovascular Therapy and Prevention. 2011;10(6):94-98. (In Russ.)

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