Inflammatory reaction in experimental non-coronary metabolic myocardial infarction
Abstract
Aim. To study inflammatory reaction specifics in Vistar rats with non-coronary metabolic myocardial infarction (MMI). Material and methods. Electrocardiographical and histological verification of MMI. Measurement of neutrophil biocide activity, antioxidant system activity, the levels of lipid peroxidation (LP) products and pro-inflammatory cytokines, and plasma lipoprotein (LP) profile assessment. Results. In MMI rats, neutrophil biocide activity was increased, the balance between pro- and antioxidant systems was disturbed, plasma LP profile was affected, with increased pro-inflammatory LP levels, and pro-inflammatory cytokine concentrations were elevated. Conclusion. The observed inflammatory reaction specifics determined the clinical course of MMI.
About the Authors
L. D. Khidirova
Novosibirsk State Medical University. Novosibirsk
Russian Federation
Russian Federation
L. V. Vokhmintseva
Novosibirsk State Medical University. Novosibirsk
Russian Federation
Russian Federation
N. N. Mayanskaya
Novosibirsk State Medical University. Novosibirsk
Russian Federation
Russian Federation
S. D. Mayanskaya
Kazan State Medical Academy. Kazan
Russian Federation
Russian Federation
V. I. Sharapov
Novosibirsk State Medical University. Novosibirsk
Russian Federation
Russian Federation
References
1. Маянский Д. Н., Цырендоржиев Д. Д., Макарова О. П. Диагностическая ценность лейкоцитарных тестов. Ч. 2: Определение биоцидности лейкоцитов: Метод. рекомендации. -Новосибирск: СО РАМН, 1996. -32 с.
2. Зенков Н.К., Ланкин В.З., Меньщикова Е.Б. Окислительный стресс. Биохимический и патофизиологический аспекты. МАИК "НАУКА/ИНТЕРПЕРИОДИКА" 2001; 343 с.
3. Игитова М.Б., Воробьева Е.В., Осипова И.В., Гольцова Н.П. Роль системного воспаления в развитии кардиоваскулярной и акушерской патологии. Кардиоваск тер профил 2009; 1:81-7.
4. Камышников B.C. Справочник по клинико-биохимической лабораторной диагностике. Минск: Изд-во "Беларусь" 2000; 2: 463 с.
5. Марри Р., Греннер Д., Мейес П., Родуэлл В. Биохимия человека. Москва: "Мир" 1993; 1: 381 с.
6. Маянский Д.Н. Лекции по клинической патологии. Москва: "ГЭОТАР-Медиа" 2008; 249 с.
7. Меерсон Ф.З. Патогенез и предупреждение стрессорных и ишемических повреждений сердца. Москва "Медицина" 1984; 272 с.
8. Ольбинская Л.И., Литвицкий П.Ф. Коронарная и миокардиальная недостаточность. Москва "Медицина" 1986; 272 с.
9. Соколов Е.И. Эмоции, гормоны и атеросклероз. Москва "Наука" 1991; 294 с.
10. Bagchi D., Das D.K., Engelman R.M., et al. Polymorphonuclear leucocytes as potential source of free radicals in the ischaemicreperfused myocardium. Eur HeartJ 1990; 11: 800-13.
11. Baggiolini M., Kheren P., Deranleau D.A., et al. Control of motility, exocytosis and the respiratory burst in human neutrophils. Biochem Soc Trans 1991; 19: 56-9.
12. Braunwald E. Approach to the patients with heart disease. In the book: Harrison's principles of internal medicine 1994; 939-41.
13. Van Lenten B.J., Navab M., Shih D., et al. The role of high-density lipoproteins in oxidation and inflammation. Trends Cardiovasc Med 2001; 1(3-4): 155-61.
Review
For citations:
Khidirova L.D., Vokhmintseva L.V., Mayanskaya N.N., Mayanskaya S.D., Sharapov V.I. Inflammatory reaction in experimental non-coronary metabolic myocardial infarction. Cardiovascular Therapy and Prevention. 2010;9(1):74-78. (In Russ.)
Views:
511
Email this article 
