Menopausal hormone therapy and heart disease prevention: desired or valid?
https://doi.org/10.15829/1728-8800-2019-3-94-106
Abstract
Cardiovascular diseases are the main cause of death for women in older age groups. For many decades, specialists have tried to prevent their development by the use of estrogen. The review of the literature presents current data on the effect of menopausal hormone therapy (MHT) on the risk of cardiovascular complications. The results of the main randomized clinical and observational studies in this area, conducted over several decades, are discussed. We described the concept of “window of opportunities”, in accordance with which an improvement in cardiovascular prognosis can be expected only at the onset of MHT in women under the age of 60 years in early postmenopause (menopause duration <10 years). There are experimental and clinical data explaining the different effects of estrogen on the cardiovascular prognosis in women of various age groups and different duration of postmenopause. The recommendations given in the review on the use of MHT are based on modern international guidelines.
About the Authors
V. I. Podzolkov
I. M. Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
A. E. Bragina
I. M. Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
N. M. Podzolkovа
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
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Podzolkov V.I., Bragina A.E., Podzolkovа N.M. Menopausal hormone therapy and heart disease prevention: desired or valid? Cardiovascular Therapy and Prevention. 2019;18(3):94-106. (In Russ.) https://doi.org/10.15829/1728-8800-2019-3-94-106
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