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Clinical and prognostic significance of bendopnea in elderly outpatients

https://doi.org/10.15829/1728-8800-2019-6-45-50

Abstract

Aim. To assess clinical and prognostic significance of dyspnea when leaning forward in elderly outpatients.

Material and methods. The open, prospective, non-randomized study included 55 outpatients >60 years old with class II-IV (NYHA) chronic heart failure (CHF) as a result of coronary artery disease or hypertension and body mass index (BMI) <30 kg/m2. Routine physical examination, laboratory tests and echocardiography were conducted.

Results. Dyspnea when leaning forward was detected in 45% of patients. Bendopnea was associated with a history of myocardial infarction (p<0,001, odds ratio (OR) 11,5, 95% confidence interval (CI) 2,7-47,8), left ventricular aneurysm (p=0,005, OR 9,4, 95% CI 1,7-54,5), increased end-systolic dimension (p=0,003, OR 18,4, 95% CI 2,69-12,5), low ejection fraction (p<0,001, OR 19, 2, 95% CI 4,46-8,23) and hospitalizations (p=0,004, OR 2,6, 95% CI 1,4-4,9).

Conclusion. Thus, 45% of patients >60 years old with a BMI <30,0 kg/ m2 had dyspnea when leaning forward. It was not depended on BMI, and was closely associated with the clinical severity, echocardiographic parameters and hospitalizations. The results obtained allow us considering this symptom as a marker of severity of clinical condition and stasis in elderly outpatients with chronic heart failure without concomitant obesity.

About the Authors

V. N. Larina
Pirogov Russian National Research Medical University
Russian Federation
Moscow.


M. G. Golovko
Pirogov Russian National Research Medical University
Russian Federation
Moscow.


M. I. Zakharova
Pirogov Russian National Research Medical University
Russian Federation
Moscow.


N. L. Bogush
Pirogov Russian National Research Medical University
Russian Federation
Moscow.


G. V. Poryadin
Pirogov Russian National Research Medical University
Russian Federation
Moscow.


References

1. Thibodeau J, Turer A, Gualano S, et al. Characterization of a novel symptom of advanced heart failure: bendopnea. JACC Heart Fail. 2014;2:24-31. doi:101016/j.jchf.2013.07.009.

2. Mareev VYu, Ageev FT, Arutyunov GP, et al. National recommendations of OSSN, RCO and RRMSP about diagnostics and treatment of HSN (fourth revision). Heart Fail. 2013; 81(7):379-472. (In Russ.)

3. Ponikowski P, Voors A, Anker S, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129-200. doi:10.1093/eurheartj/ehw128.

4. KDIGO 2012 Clinical Practice Guidelines for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2013;3(1):1-163.

5. Kositskiy GI. Afferentnyye sistemy serdtsa. “Meditsina”, Moscow, 1975. 207 р. (In Russ.)

6. Thibodeau J, Jenny B. Maduka J, et al. Bendopnea and risk of adverse clinical outcomes in ambulatory patients with systolic heart failure. Am Heart J. 2017;183:102-7. doi:10.1016/j.ahj.2016.09.011.

7. Van Gaal L, Mertens I, De Block C. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875-80.

8. Lavie CJ, Alpert MA, Arena R, et al. Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure. JACC HF. 2013;1:93-102. doi:101016/j.jchf.2013.01.006. Epub 2013 Apr 1.

9. Turkbey EB, McClelland RL, Kronmal RA, et al. The impact of obesity on the left ventricle. The Multi-Ethnic Study of Atherosclerosis (MESA). JACC Img. 2010;3:266-74. doi:10.1016/j.jcmg.2009.10.012.

10. Baeza-Trinidad R, Mosquera-Lozano J, Bikri L. Assessment of bendopnea impact on decompensated heart failure. Eur J Heart Fail. 2017;19:111-5. doi:10.1002/ejhf.610.

11. Ceron M, Rosa G, Jorge L, et al. Association of types of dyspnea including 'bendopnea' with cardiopulmonary disease in primary care. Rev Port Cardiol. 2017;3(36):179-86. doi:10.1016/j.repc.2016.08.007.

12. Larina VN, Bart BY, Chukaeva II, et al. Bendopnea: Association With Echocardiographic Features and Clinical Outcomes in Elderly Patients With Chronic Heart Failure. Kardiologiia. 2018;58(12):36-44. (In Russ.)

13. Dragunov DO, Sokolova AV, Arutyunov GP, et al. Bendopnea as a predictor of chronic heart failure decompensation. Clin Pharmacol Ther. 2018;27(5):52-7. (In Russ.)

14. Sajeev C, Nair S, George B, et al. Demographical and clinicopathological characteristics in heart failure and outcome predictors: a prospective, observational study. ESC Heart Fail. 2017;4:16-22. doi:10.1002/ehf2.12119.


Review

For citations:


Larina V.N., Golovko M.G., Zakharova M.I., Bogush N.L., Poryadin G.V. Clinical and prognostic significance of bendopnea in elderly outpatients. Cardiovascular Therapy and Prevention. 2019;18(6):45-50. (In Russ.) https://doi.org/10.15829/1728-8800-2019-6-45-50

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)