Cytokine status in patients with myocardial infarction as a possible predictor of coronary atherosclerosis severity
https://doi.org/10.15829/1728-8800-2020-2316
Abstract
Aim. To study the association of cytokine status with coronary atherosclerosis severity in patients with myocardial infarction (MI).
Material and methods. Between 11.2018 and 07.2019, 92 patients hospitalized with MI in Perm Clinical Cardiology Dispensary were included in the study. The control group consisted of 23 patients with stable coronary artery disease. In addition to the standard examination, enzyme-linked immunosorbent assay was used to determine the levels of interleukins (IL)-6, -10, tumor necrosis factor alpha (TNF-α), C-reactive protein.
Results. Significant increase in plasma IL-6, TNF-α and C-reactive protein levels in MI patients compared with the control group. The increase in the concentration of IL-6, TNF-α, as well as the IL-6/IL-10 ratio occurs in proportion to coronary atherosclerosis severity. A direct correlation of Gensini score with IL-6, TNF-α, and IL-6/IL-10 ratio was established.
Conclusion. Further study of cytokine profile parameters in MI patients will help a clearer understanding pathogenesis of coronary artery atherosclerosis. An increase in concentrations of IL-6, TNF-α, and IL-6/IL-10 ratio is associated with an increase in coronary atherosclerosis severity and can be used in practice for its prediction.
About the Authors
O. V. Khlynova
E.A. Wagner Perm State Medical University
Russian Federation
Russian Federation
Corresponding Member of the RAS, Doctor of Medicine, Professor, Head of the Hospital Therapy Department
Perm
E. A. Shishkina
E.A. Wagner Perm State Medical University
Russian Federation
Russian Federation
Candidate of Medical Science, Associate Professor at the Hospital Therapy Department
Perm
N. I. Abgaryan
Clinical Cardiology Dispensary
Russian Federation
Russian Federation
Cardiologist at Clinical Cardiology dispensary, external researcher at the Hospital Therapy Department
Perm
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Review
For citations:
Khlynova O.V., Shishkina E.A., Abgaryan N.I. Cytokine status in patients with myocardial infarction as a possible predictor of coronary atherosclerosis severity. Cardiovascular Therapy and Prevention. 2020;19(3):2316. (In Russ.) https://doi.org/10.15829/1728-8800-2020-2316
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