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Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension

https://doi.org/10.15829/1728-8800-2020-2422

Abstract

Aim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH).

Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood pressure (BP), and there was no history of its increase. We conducted 24-hour ambulatory blood pressure monitoring (ABPM), carotid duplex scan with determination of the intima- media thickness (IMT). The levels of total cholesterol (TC), low (LDLC) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) were determined. Body mass index, visceral adiposity index, lipid accumulation product index and waist-to-height ratio were calculated. We performed clustering of ABPM data, calculated the odds ratio of association between cardiometabolic risk factors and certain MH phenotypes.

Results. MH was diagnosed in 142 (68,6%) patients examined, divided into 3 clusters: systolic-diastolic — SDMH (50,7%), isolated systolic — ISMH (27,5%) and isolated diastolic — IDMH (21,8%). Impaired lipid metabolism, visceral adiposity, IMT increase and atherosclerotic plaques were more often recorded in patients with SDMH and IDMH. The levels of TC, LDL-C and IMT were highest in individuals with IDMH. Odds ratio analysis indicated significant associations of SDMH and IDMH phenotypes with indicators of visceral adiposity, IMT, TG, TC, LDL-C and TG/HDL-Cl.

Conclusion. Clustering of ABPM data in individuals with MH and comparing related phenotypes with cardiometabolic risk factors complements their clinical and functional characteristics and can be a useful tool for improving customized prevention and therapy programs.

About the Authors

B. I. Geltser
Far Eastern Federal University
Russian Federation

Director of the department of clinical medicine of the School of biomedicine

Vladivostok



V. V. Orlova-Ilinskaya
Far Eastern Federal University
Russian Federation

Student School of biomedical

Vladivostok



O. O. Vetrova
Far Eastern Federal University
Russian Federation

Post-graduate School of biomedical

Vladivostok



V. N. Kotelnikov
Far Eastern Federal University
Russian Federation

Professor of the department of clinical medicine of the School of biomedicine

Vladivostok



R. S. Karpov
Tomsk National Research Medical Center, Cardiology Research Institute
Russian Federation

Supervisor

Tomsk



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Review

For citations:


Geltser B.I., Orlova-Ilinskaya V.V., Vetrova O.O., Kotelnikov V.N., Karpov R.S. Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension. Cardiovascular Therapy and Prevention. 2020;19(4):2422. (In Russ.) https://doi.org/10.15829/1728-8800-2020-2422

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)