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Кардиоваскулярная терапия и профилактика

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Эпигенетика ожирения

https://doi.org/10.15829/1728-8800-2020-2632

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Аннотация

Патофизиология ожирения чрезвычайно сложна и включает в себя изменения пищевого поведения, генетические и эпигенетические факторы, воздействие факторов окружающей среды и многое другое. На сегодняшний день ~40 генетических полиморфизмов связаны с ожирением и распределением жира. Однако, поскольку эти варианты не в полной мере объясняют наследственность ожирения, необходимо рассмотреть другие варианты, такие как эпигенетические изменения. Эпигенетические модификации влияют на экспрессию генов без фактического изменения последовательности дезоксирибонуклеиновой кислоты. Кроме того, воздействие окружающей среды в критические периоды развития может повлиять на профиль эпигенетических меток и привести к ожирению. Более глубокое понимание эпигенетических механизмов, лежащих в основе ожирения, может помочь в профилактике, основанной на изменениях образа жизни. Данный обзор сфокусирован на роли эпигенетических модификаций в развитии ожирения и ассоциированных с ним состояний.

Об авторах

О. М. Драпкина
ФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава России
Россия
Оксана Михайловна Драпкина - доктор медицинских наук, профессор, член-корр. РАН, директор

Москва



О. Т. Ким
ФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава России
Россия

Ольга Трофимовна Ким - младший научный сотрудник отдела фундаментальных и прикладных аспектов ожирения

Москва



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Для цитирования:


Драпкина О.М., Ким О.Т. Эпигенетика ожирения. Кардиоваскулярная терапия и профилактика. 2020;19(6):2632. https://doi.org/10.15829/1728-8800-2020-2632

For citation:


Drapkina O.M., Kim O.T. Epigenetics of obesity. Cardiovascular Therapy and Prevention. 2020;19(6):2632. (In Russ.) https://doi.org/10.15829/1728-8800-2020-2632

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)