Familial dysbetalipoproteinemia: highly atherogenic and underdiagnosed disorder
https://doi.org/10.15829/1728-8800-2021-2893
Abstract
Familial dysbetalipoproteinemia (FD) is a genetic, highly atherogenic disorder. The penetrance of FD depends on the patient’s lifestyle and concomitant diseases. Despite the fact that FD was described almost half a century ago, it is still insufficiently studied and is extremely rarely diagnosed. In actual clinical practice, physicians do not have clear understanding of clinical course and genetic basis of FD. The aim was to present the most complete, but at the same time a critical review with a modern view on FD. We analyzed Russian and foreign publications from following electronic databases: PubMed, eLIBRARY, Google Scholar. As a result, the phenotypic features and genetic variability of the disease were considered and the main issues of diagnosis and treatment of patients with FD were discussed. The data presented will help the clinician to timely suspect the FD, conduct a full range of investigations and prescribe evidence-based lipid-lowering therapy.
About the Authors
A. V. Blokhina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Clinical resident, laboratory researcher, laboratory of Clinomics. SPIN:1103-6168.
Moscow, +7 (916) 170-87-25
A. I. Ershova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
MD, PhD, Head of the Laboratory of Clinomics. SPIN: 5292-5612.
Moscow
A. N. Meshkov
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
MD, PhD, Head of the Laboratory of Molecular genetics. SPIN: 6340-5187.
Moscow
O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
MD, Professor, Director of the National Medical Research Center for Therapy and Preventive Medicine. SPIN: 4456-1297.
Moscow
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For citations:
Blokhina A.V., Ershova A.I., Meshkov A.N., Drapkina O.M. Familial dysbetalipoproteinemia: highly atherogenic and underdiagnosed disorder. Cardiovascular Therapy and Prevention. 2021;20(6):2893. (In Russ.) https://doi.org/10.15829/1728-8800-2021-2893
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