KIDNEY DYSFUNCTION EVALUATION IN CHRONIC HEART FAILURE PATIENTS
https://doi.org/10.15829/1728-8800-2014-2-51-54
Abstract
Aim. To study the signs of kidney dysfunction in chronic heart failure (CHF).
Material and methods. We included 96 patients with postinfarction cardiosclerosis and CHF with the age of 40–60 years. Patients were divided into two groups by functional class (FC) of CHF according to NYHA. In all patients the levels of serum creatinine and MDRD glomerular filtration rate (GFR), urine alanine transferase, aspartat transferase, alkaline phosphatase and cholinaestherase by spectrophotometric method were measured.
Results. In 33,3% of patients with II FC NYHA and in 66,67% with III FC NYHA we found GFR less than 60 ml/min/1,73 sq.m. Investigation of fermenturia levels in those according to renal functioning showed more prevalent increase of urine enzymes in lower GFR, in whom the patients with III FC NYHA consisted 66,67%. The level of ALT was 39% (p<0,01) higher and AP 35% (p<0,001) higher comparing to subjects without renal dysfunction.
Conclusion. In patients with chronic heart failure as the diseases progresses there is kidney dysfunction developing with the decrease of GFR, increase of resdual nitrogen and enzimes in urine. Enzyme levels testing in urine of CHF patients can be a part of diagnostic approach to kidney dysfunction diagnostic at earlier stages.
About the Authors
U. K. Kamilova
Republican Specialized Centre of Cardiology
Tashkent Medicine Academy, Tashkent, Uzbek Republic
Uzbekistan
Uzbekistan
I. T. Alikulov
Tashkent Medicine Academy, Tashkent, Uzbek Republic
Uzbekistan
Uzbekistan
References
1. Engelfriet PM, Hoogenveen RT, Boshuizen HC, et al. To die with of from heart failure: a difference that counts: is heart failure underrepresented in national mortality statistics? Eur J Heart Fail 2011; (13): 37–38.
2. Miyagishima K, Hiramitsu S, Kimura H, et al. Long term prognosis of chronic heart failure: reduced vs preserved left ventricular ejection fraction. Circulation 2009; 73 (1): 92–9.
3. Arutunov GP. Pathophysiological processes in kidneys of patients with CHF. J Heart Faiul 2008; 9 (5): 234–49. Russian (Арутюнов Г. П. Патофизиологические процессы в почках у больных ХСН. Сердечная недостаточность 2008; 9 (5): 234–49).
4. Bock JS, Gottlieb SS. Cardiorenal syndrome: new perspectives. Circulation 2010; 21: 2592.
5. Berl T, Henrich W. Kidney-Heart interactions: Epidemio logy, pathogenesis, and treatment. Clin J Am Soc Nephrol 2006; 1: 8–18.
6. Eilers H, Liu KD, Gruber A, Niemann CU. Chronic kidney disease: implications for the perioperative period. Minerva Anestesiol 2010; 76 (9): 725–36.
7. Bakris GL, Sera dis PA, Weir MR, et al. ACCOMPLISH Trial Investigators. Renal outcomes with different xed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespeci ed secondary analysis of randomised controlled trial. Lancet 2010; 375: 1173–81.
8. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int (Suppl.) 2013; 3: 1–150.
9. Whaley-Connell AT, Vassalotti JA, Collins AJ, et al. National Kidney Foundation’s Kidney Early Evaluation Program (KEEP) Annual Data Report 2011: Executive Summary. Am J Kidney Dis 2012; 59 (3) (Suppl 2): S1–4.
10. Pokhrel N, Maharjan N, Dhakal B, et al. Cardiorenal syndrome: A literature review. Exp Clin Cardiol 2008; 13 (4): 165–70.
11. Renal function and prediction of cardiovascular risk. Cardiovascular Therapy and Prevention 2008; 7 (6). Appendix 3. Russian (Функциональное состояние почек и прогнозирование сердечно-сосудистого риска. Рекомендации ВНОК и НОНР. Кардиоваскулярная терапия и профилактика 2008; 7 (6). Приложение 3).
12. Plischke M, Neuhold S, Kohl M, et al. Renal function in heart failure: a disparity between estimating function and predicting mortality risk. Eur J Heart Fail 2013; 15 (7): 763–70.
13. Ronco C, Chionh CY, Haapio M, et al. The cardiorenal syndrome. Blood Purif 2009; 27 (1): 114–26.
14. Mavlyanov IR, Akbarova GP, Khabilova NL. The renal tubular epithelial system in patients with rheumatoid arthritis in relation to its duration. Profilac Medicine 2009; 3: 14–9. Russian (Мавлянов И. Р., Акбарова Г. П., Хабилова Н. Л. Состояние тубулоэпителиальной системы почек у больных ревматоидным артритом в зависимости от длительности заболевания. Профилактическая медицина 2009; 3: 14–9).
15. Soni S, Fahuan Y, Ronco C, et al. Cardiorenal syndrome: biomarkers linking kidney damage with heart failure. Biomarkers Med 2009; 3 (5): 549–60.
Review
For citations:
Kamilova U.K., Alikulov I.T. KIDNEY DYSFUNCTION EVALUATION IN CHRONIC HEART FAILURE PATIENTS. Cardiovascular Therapy and Prevention. 2014;13(2):51-54. (In Russ.) https://doi.org/10.15829/1728-8800-2014-2-51-54
Views:
1162
Email this article 
