Relation of the heart remodeling and endothelial dysfunction in chronic heart failure patients
https://doi.org/10.15829/1728-8800-2016-1-16-19
Abstract
Aim. To study relation of the heart remodeling processes and endothelial dysfunction in patients with chronic heart failure (CHF).
Material and methods. Totally, 103 patients studied with post infarction cardiosclerosis. All patients selected to 3 groups by functional class (FC): I group consisted of 28 patients with CHF I FC, II — 46 patients with II FC and III — 29 patients with III FC by NYHA. All patients underwent echocardiography, dopplerography of brachial artery.
Results. Post infarction remodeling of the left ventricle (LV) led not
only to structural remodeling of LV, with chamber dilation, walls
thinning, contractility decrease, but to changes of LV geometry.
Contractility decrease of LV myocardium followed by the disordered
endothelium-dependent vessel dilation, with increase of pulsative and
resistive indexes, sensitivity decrease of brachial artery to the shift
tension.
Conclusion. In CHF patients the processes of heart remodeling followed by remodeling of vessels, showing functional and humoral parameters of endothelial dysfunction.
Material and methods. Totally, 103 patients studied with post infarction cardiosclerosis. All patients selected to 3 groups by functional class (FC): I group consisted of 28 patients with CHF I FC, II — 46 patients with II FC and III — 29 patients with III FC by NYHA. All patients underwent echocardiography, dopplerography of brachial artery.
Results. Post infarction remodeling of the left ventricle (LV) led not
only to structural remodeling of LV, with chamber dilation, walls
thinning, contractility decrease, but to changes of LV geometry.
Contractility decrease of LV myocardium followed by the disordered
endothelium-dependent vessel dilation, with increase of pulsative and
resistive indexes, sensitivity decrease of brachial artery to the shift
tension.
Conclusion. In CHF patients the processes of heart remodeling followed by remodeling of vessels, showing functional and humoral parameters of endothelial dysfunction.
About the Authors
Ch. A. Abdullaeva
Tashkent Medical Academy. Tashkent
Uzbekistan
Uzbekistan
U. K. Kamilova
Ташкентская медицинская академия. Ташкент;
Республиканский специализиpованный научно-практический медицинский центp теpапии и медицинской реабилитации. Ташкент
Uzbekistan
1.Tashkent Medical Academy. Tashkent;
2.Republic Specialized Scientific-Practical Medical Center for Internal Medicine and Medical Rehabilitation. Tashkent
Uzbekistan
1.Tashkent Medical Academy. Tashkent;
2.Republic Specialized Scientific-Practical Medical Center for Internal Medicine and Medical Rehabilitation. Tashkent
References
1. Engelfriet PM, Hoogenveen RT, Boshuizen HC, et al. To die with of from heart failure: a difference that counts: is heart failure underrepresented in national mortality statistics? Eur J Heart Fail 2011; (13): 377-80.
2. Sherazi S, Zaręba W. Diastolic heart failure: Predictors of mortality Cardiology Journal 2011; 18(3): 222-32.
3. Gaasch WH, Delorey DE, St John Sutton MG, Zile MR. Patterns of structural and functional remodeling of the left ventricle in chronic heart failure. Am J Cardiol 2008; 102(4): 459-62.
4. Desai RV, Meyer P, Ahmed MI, et al. Relationship between left and right ventricular ejection fractions in chronic advanced systolic heart failure: insights from the BEST trial. Eur J Heart Failure 2010; 13: 392-7.
5. Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J 2012; 33(14): 1750-7.
6. Nguyen JS, Lakkis NM, Bobek J, et al. Systolic and diastolic myocardial mechanics in patients with cardiac disease and preserved ejection fraction: impact of left ventricular filling pressure. J Am Soc Echocardiogr 2010; 23(12): 1273-80.
7. Niebauer J. Effects of exercise training on inflammatory markers in patients with heart failure. Heart Fail Rev 2008; 13(1): 39-49.
8. Fischer D, Rossa S, Landmesser U, et al. Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiactransplantation, or death. Eur Heart J 2005; 26: 65-9.
9. Bauersachs J, Widder JD. Endothelial dysfunction in heart failure. Pharmacological Reports 2008; 60:119-26.
10. Horn P, Cortese-Krott MM, Nicolas A, et al. Circulating microparticles carry a functional endothelial Nitric Oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc 2012; 2: e003764
11. Hsieh HJ, Liu CA, Huang B, et al. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci 2014 Jan 13; 21(1): 3. doi: 10.1186/1423-0127-21-3.
12. Deanfield J, Donald A, Ferri C, et al. Endothelial function and dysfunction. Part 1: Methodological issues for assessment in the different vascular beds: A statement by the Working group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005; 23(1): 7-16.
13. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005; 111: 363-8.
Review
For citations:
Abdullaeva Ch.A., Kamilova U.K. Relation of the heart remodeling and endothelial dysfunction in chronic heart failure patients. Cardiovascular Therapy and Prevention. 2016;15(1):16-19. (In Russ.) https://doi.org/10.15829/1728-8800-2016-1-16-19
Views:
766
Email this article 
