Vascular control over blood cells aggregation in patients with arterial hypertension with dyslipidemia
https://doi.org/10.15829/1728-8800-2016-1-4-9
Abstract
There is a marked increase of prevalence of arterial hypertension (AH) in modern civilized society that usually is comorbid with dyslipidemia (DL), which leads to higher level of vascular comorbidity in economically active population, disability and mortality.
Aim. To find out the specifics of antiplatelet vascular control over blood
cells in AH patients with DL.
Material and methods. Totally, we studied 380 patients with AH of 1-2 grade, risk 4, with DL IIb type, of middle age. Controls were 26 healthy volunteers of the same age. We used biochemical, hematological and statistical methods of investigation.
Results. In the blood of patients, there was DL IIb type revealed, with
weakening of antioxidant defense and high level of lipid peroxidation. In
the studied patients with AH and DL there was increased level of
erythrocyte, platelet and neutrophil aggregation with decrease of the
control by vascular wall. These findings can be explained by negative
shifts of lipid metabolism, activation of peroxide oxidation of plasma
lipids, receptor rebuilt of blood cells and decrease of synthesis in
vascular walls of nitric oxide and prostacyclin.
Conclusion. For AH with DL patients it is specific to have decreased
control of vascular wall over the increased aggregation of erythrocytes,
platelets and neutrophils.
Aim. To find out the specifics of antiplatelet vascular control over blood
cells in AH patients with DL.
Material and methods. Totally, we studied 380 patients with AH of 1-2 grade, risk 4, with DL IIb type, of middle age. Controls were 26 healthy volunteers of the same age. We used biochemical, hematological and statistical methods of investigation.
Results. In the blood of patients, there was DL IIb type revealed, with
weakening of antioxidant defense and high level of lipid peroxidation. In
the studied patients with AH and DL there was increased level of
erythrocyte, platelet and neutrophil aggregation with decrease of the
control by vascular wall. These findings can be explained by negative
shifts of lipid metabolism, activation of peroxide oxidation of plasma
lipids, receptor rebuilt of blood cells and decrease of synthesis in
vascular walls of nitric oxide and prostacyclin.
Conclusion. For AH with DL patients it is specific to have decreased
control of vascular wall over the increased aggregation of erythrocytes,
platelets and neutrophils.
About the Authors
I. N. Medvedev
Kursk Institute of Social Education (filial) of Russian State Social University. Kursk
Russian Federation
Russian Federation
I. A. Skorjatina
Kursk Institute of Social Education (filial) of Russian State Social University. Kursk
Russian Federation
Russian Federation
S. Yu. Zavalishina
Kursk Institute of Social Education (filial) of Russian State Social University. Kursk
Russian Federation
Russian Federation
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Review
For citations:
Medvedev I.N., Skorjatina I.A., Zavalishina S.Yu. Vascular control over blood cells aggregation in patients with arterial hypertension with dyslipidemia. Cardiovascular Therapy and Prevention. 2016;15(1):4-9. (In Russ.) https://doi.org/10.15829/1728-8800-2016-1-4-9
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