Согласованное мнение российских экспертов по оценке артериальной жесткости в клинической практике

За последние годы было опубликовано множество исследований по определению жесткости артерий, доказана важность определения сосудистой жесткости как независимого прогностического показателя в совокупности со стандартными факторами сердечно- сосудистого риска. В представленном документе объединены и систематизированы имеющиеся клинические и научные данные зарубежных и российских исследований в этом направлении. Целью настоящей публикации является необходимость донести до читателя важность исследования жесткости артериальной стенки, наиболее распространенные и востребованные в клинической практике способы ее определения, информацию о состояниях, при которых следует оценивать сосудистую жесткость, существующие ограничения, а также вопросы, которые в настоящее время остаются нерешенными в этой области. 

1. Van Bortel LM, Laurent S, Boutouyrie P, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 2012; 30: 445-8.

2. Fundamental Clinical Physiology. Ed. AG Kamkin and AA Kamensky. Moscow: “Academia” Publishing Center. 2004: 31-43. Russian (Фундаментальная клиниче- ская физиология. Под ред. А.Г. Камкина и А.А. Каменского. Москва: издательский центр “Академия”. 2004: 31-43).

3. Bronwyn A Kingwell, Tamara K Waddell, Tanay L Medley, et al. Large Artery Stiffness Predicts Ischemic Threshold in Patients With Coronary Artery Disease. JACC 2002; 40 (4): 773-9.

4. Mitchell G.F. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol 2008; 105: 1652-60.

5. Nichols WW, O’Rourke MF. McDonald’s blood flow in arteries. Theoretical, Experimental and Clinical Principles. 5th ed. Oxford University Press; 2005: 624.

6. Latham RD, Westerhof N, Sipkema P, et al. Regional wave travel and reflections along the human aorta: a study with six simultaneous micromanometric pressures. Circulation 1985; 72: 1257-69.

7. Isnard RN, Pannier BM, Laurent S, et al. Pulsatile diameter and elastic modulus of the aortic arch in essential hypertension: a noninvasive study. JACC 1989;13: 399-405.

8. Laurent S, Caviezel B, Beck L, et al. Carotid artery distensibility and distending pressure in hypertensive humans. Hypertension 1994; 23: 878-83.

9. Laurent S, Hayoz D, Trazzi S, et al. Isobaric compliance of the radial artery is increased in patients with essential hypertension. J Hypertens 1993; 11: 89-98.

10. Boutouyrie P, Lacolley P, Girerd X, et al. Sympathetic activation decreases radial artery compliance in humans. Am J Physiol 1994; 267: H1368-76.

11. Giannattasio C, Failla M, Lucchina S, et al. Arterial stiffening influence of sympathetic nerve activity: evidence from hand transplantation in humans. Hypertension. 2005; 45: 608-11.

12. Giannattasio C, Failla M, Stella ML, et al. Angiotensin-converting enzyme inhibition and radial artery compliance in patients with congestive heart failure. Hypertension 1995; 26: 491-6.

13. Taylor MG. Wave travel in arteries and the design of the cardiovascular system. In: Attinger EO, ed. Pulsatile Blood Flow. New York, NY, USA: McGraw Hill 1964; 343-7.

14. Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA. Microcirculation in hypertension: a new target for treatment? Circulation 2001; 104: 735-40.

15. Safar ME, Van Bortel LM, Struijker Boudier HA. Resistance and conduit arteries following converting enzyme inhibition in hypertension. J Vasc Res 1997; 34: 67-81.

16. Struijker-Boudier HA, Cohuet GM, Baumann M, Safar ME. The heart, macrocirculation and microcirculation in hypertension: a unifying hypothesis. J Hypertens Suppl 2003; 2: S19-23.

17. Bezie Y, Lamaziere JM, Laurent S, et al. Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 1998; 18: 1027-34.

18. Fischer GM, Llaurado JG. Collagen and elastin content in canine arteries selected from functionally different vascular beds. Circ Res 1966; 19: 394-9.

19. Laurent S, Boutouyrie P, Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension 2005; 45: 1050-5.

20. Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27: 2588-605.

21. Colin D, Jonathan N, Richard P, et al. Arterial stiffness in chronic kidney disease: causes and consequences. Heart 2010; 96: 817-23.

22. Van Popele N, Grobbee D, Bots M, et al. Association between arterial stiffness and atherosclerosis: the Rotterdam study. Stroke 2001; 32: 454-60.

23. Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension. a systematic review. Hypertension 2009; 54: 1328-36.

24. Yun J, Kim JY, Kim OY, et al. Associations of plasma homocysteine level with brachialankle pulse wave velocity, LDL atherogenicity, andinflammation profile in healthy men. Nutr Metab Cardiovasc Dis 2011; 21 (2): 136-43.

25. Avest E, Holewijn S, Bredie SJ, et al. Pulse wave velocity in familial combined hyperlipidemia. Am J Hypertens 2007; 20: 263-9.

26. Aoun S, Blacher J, Safar ME, et al. Diabetes mellitus and renal failure: effects on large artery stiffness. J Hum Hypertens 2001; 15 (10): 693-700.

27. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’ / The Reference Values for Arterial Stiffness’ Collaboration. Eur Heart J 2010; 31: 2338-50.

28. Manuel A Gomez-Marcos, Jose I Recio-Rodríguez, Maria C Patino-Alonso, et al. Relationships between high-sensitive C-reactive protein and markers of arterial stiffness in hypertensive patients. Differences by sex. BMC Cardiovascular Disorders. 2012; 12-37. http// www.biomedcentral.com/1471-2261/12/37

29. Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study. Circulation 2006; 113: 657-63.

30. Townsend RR, Wilkinson IB, Schiffrin EL, et al.; American Heart Association Council on Hypertension. Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness. A Scientific Statement from the American Heart Association. J Hypertension 2015 Sep; 66(3): 698-722.

31. Asmar R, Benetos A, Topouchian J, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 1995; 26: 485-90.

32. Van der Heijden-Spek JJ, Staessen JA, Fagard RH, et al. Effect of age on brachial artery wall properties differs from the aorta and is gender dependent: a population study. Hypertension 2000; 35: 637-42.

33. Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002; 106: 2085-90.

34. Chiu YC, Arand PW, Shroff SG, et al. Determination of pulse wave velocities with computerized algorithms. Am Heart J 1991; 121: 1460-70.

35. Van Bortel LM, Duprez D, Starmans-Kool MJ, et al. Applications of arterial stiffness, Task Force III: recommendations for user procedures. Am J Hypertens 2002; 15: 445-52.

36. Nichols WW, McDonald DA. Wave-velocity in the proximal aorta. Med Biol Eng 1972; 10: 327-35.

37. National guidelines on the management of patients with vascular arterial pathology (Russian coglasitelny document). Part 1. Peripheral artery. — M.: Izd AN Bakuleva SСCVS. 2010. 176 p. Russian (Национальные рекомендации по ведению пациентов с сосудистой артериальной патологией (Российский cогласительный документ). Часть 1. Периферические артерии. — М.: Изд-во НЦССХ им. А.Н. Бакулева РАМН. 2010. 176 с).

38. Recommendations of the European Society of Cardiology for the diagnosis and treatment of peripheral arterial disease, 2011. Rational pharmacotherapy in cardiology 2012; Appendix №4: 4-73. Russian (Рекомендации европейского общества кардиологов по диагностике и лечению заболеваний периферических артерий, 2011. Рациональная фармакотерапия в кардиологии 2012; Приложение №4: 4-73).

39. Ibata J, Sasaki H, Kakimito T, et al. Cardio-ankle vascular index measures arterial wall stiffness independent of blood pressure. Diabetes Res Clin Pract 2008; 80(2): 265-70.

40. Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb 2006; 13(2): 101-7.

41. Okura T, Watanabe S, Kurata M, et al. Relationship between cardio-ankle vascular index (CAVI) and carotid atherosclerosis in patients with essential hypertension. Hypertens Res 2007; 30(4): 335-40.

42. Okura T, Wang L, Fang P, et al. Evaluation on cardio-ankle vascular index derived from ultrasound. Zhonghua Xin Xue Guan Bing Za Zhi 2008; 36(8): 750-3.

43. Trifonova, S, Gaisenak OV, Sidorenko BA. Application of methods of assessment of vascular stiffness in clinical practice: the possibility of cardio-ankle vascular index (CAVI). Kardiologiia 2015; (4): 55-61. Russian (Трифонова С.С., Гайсёнок О.В., Сидоренко Б.А. Применение методов оценки жесткости сосудистой стенки в клинической практике: возможности сердечно-лодыжечного сосудистого индекса (CAVI). Кардиология 2015; (4): 55-61).

44. Rogoza AN, Kaveshnikov VS, Trubacheva IA, et al. The state of the vascular wall in the population of the adult population on the example of the inhabitants of the city of Tomsk, according to a study ESSE-RF. Systemic hypertension 2014; 11 (4): 42-8. Russian (Рогоза А.Н., Кавешников В.С., Трубачева И.А. и др. Состояние сосудистой стенки в популяции взрослого населения на примере жителей города Томска, по данным исследования ЭССЕ-РФ. Системные гипертензии 2014; 11 (4): 42-8).

45. Sumin AN, Osokina AV, Shcheglova AV, et al. Can I use the cardio-ankle vascular index to estimate the prevalence of atherosclerosis in patients with coronary heart disease. Siberian Medical Journal 2014; (1): 45-9. Russian (Сумин А.Н., Осокина А.В., Щеглова А.В. и др. Можно ли с помощью сердечно-лодыжечного сосудистого индекса оценить распространенность атеросклероза у больных ишемической болезнью сердца. Сибирский медицинский журнал 2014; (1): 45-9).

46. Aliyeva AS, Boyarinova MA, Moguchaya EV, et al. Markers of subclinical arterial disease in a sample of residents of St. Petersburg (according to ESSE-RF). Arterial hypertension 2015; 21 (3): 241-51. Russian (Алиева А.С., Бояринова М.А., Могучая Е.В. и др. Маркеры субклинического поражения артерий в выборке жителей Сант-Петербурга (по данным ЭССЕ-РФ). Артериальная гипертензия 2015; 21 (3): 241-51).

47. Kobalava JD, Kotovskaya YV, Makarova MA, Villevalde SV. High systolic pressure: emphasis on arterial elasticity. Cardiovascular Therapy and Prevention 2006; 5 (6): 10-6. Russian (Кобалава Ж.Д., Котовская Ю.В., Макарова М.А., Виллевальде С.В. Высокое систолическое давление: акцент на эластические свойства артерий. Кардиоваскулярная терапия и профилактика 2006: 5(6); 10-6).

48. Magamedkerimova FA, Malkova MI, Khalilov IG, Hasanov NR. CAVI index in patients with chronic arterial insufficiency. Bulletin of Contemporary Clinical Medicine 2014; 7 (2): 104-10. Russian (Магамедкеримова Ф.А., Малкова М.И., Халилов И.Г., Хасанов Н.Р. Индекс CAVI у больных хронической артериальной недостаточностью. Вестник современной клинической медицины 2014; 7 (2): 104-10).

49. inchak RM, Komkov DS, Prischepa OG, Shvabskaya OB. Evaluation of arterial stiffness using cardio-ankle vascular index (CAVI) in a private office (departments) of medical prevention. Cardiovascular Therapy and Prevention. 2014; 13 (1): 40-3. Russian (Линчак Р.М., Комков Д.С., Прищепа О.Г., Швабская О.Б. Оценка жест- кости артерий с помощью сердечно-лодыжечного индекса (CAVI) в условиях кабинетов (отделений) медицинской профилактики. Кардиоваскулярная тера- пия и профилактика 2014; 13 (1): 40-3).

50. Oleynikov VE, Matrosova IB, Tomashevskaya YA, Gerasimova AS. Effect of ACE inhibitor spiraprila on structural and functional characteristics of the vascular wall in the metabolic syndrome, and essential hypertension. Russian Cardiology Journal 2006; 2 (58): 36-41. Russian (Олейников В.Э., Матросова И.Б., Томашевская Ю.А., Герасимова А.С Влияние ингибитора АПФ спираприла на структурно-функциональные свойства сосудистой стенки при метаболическом синдроме и эссенциальной гипертонии. Российский кардиологический журнал 2006; 2 (58): 36-41).

51. Milyagin VA, Milyagina IV, Abramenkova NY, et al. Non-invasive methods for investigating the main vessels. Smolensk. 2012. 224 p. Russian (Милягин В.А., Милягина И.В., Абраменкова Н.Ю. и др. Неинвазивные методы исследования магистральных сосудов. Смоленск. 2012. 224 с).

52. The Task Force for the management of arterial hypertension of the European Society of Hypertension and of the European Society of Cardiology. 2013 Guidelines for the management of arterial hypertension. Eur Heart J 2013; 34 (28): 2159-219. 53. Chirinos JA, Zambrano JP, Chakko S, et al. Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease. J Hypertens 2005; 45 (5): 980-5. 54. Safar ME, Blacher J, Pannier B, et al. Central pulse pressure and mortality in end– stage renal disease. J Hypertens 2002; 39 (3): 735-8.

53. Safar ME, Levy BI, Struijker–Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular disease. Circ J 2003; 107: 2864-9.

54. Abassade P, Baudouy Y. Relationship between arterial distensibility and left ventricular function in the timing of Korotkoff sounds (QKD internal). An ambulatory pressure monitoring and echocardiography study. Am J Hypertens 2002; 15: A67-8.

55. Mahmud A, Feely J. Spurious systolic hypertension of youth: fit young men with elastic arteries. Am J Hypertens 2003; 16: 229-32.

56. McEniery CM, Yasmin Wallace S, Maki-Petaja K, et al. Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults. Hypertension 2005; 46: 221-6.

57. Shupenina EY, Vasyuk JA, Nesterova EA, Ivanova SV. Effect of combined antihypertensive therapy on aortic stiffness parameters of diurnal and central blood pressure in patients with hypertension and obesity. Russ J Cardiol 2015; 12 (128): 50-5. Russian (Шупенина Е.Ю., Васюк Ю.А., Нестерова Е.А., Иванова С.В. Влияние комбинированной антигипертензивной терапии на суточные параметры жесткости аорты и центральное артериальное давление у больных артериальной гипертензией и ожирением. Российский кардиологический журнал 2015; 12 (128): 50-5.

58. Nilsson PM, Lurbe E, Laurent S. The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome (review). J Hypertens 2008; 26: 1049-57.

59. O’Rourke MF, Hashimoto J. Mechanical factors in arterial aging. A clinical perspective. JACC 2007; 50: 1113.

60. Laurent S, Boutouyrie P. Recent advances in arterial stiffness and wave reflection in human hypertension. Hypertension 2007; 49: 1202-6.

61. Ben-Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant metaanalysis of prospective observational data from 17,635 subjects. JACC 2014; 63: 636-46. doi: 10.1016/j. jacc.2013.09.063.

62. Mancia G, De Backer G, Dominiczak A, et al. Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH ) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25: 1105-87.

63. Diagnosis and treatment of hypertension. Russian Medical Society Recommendations for hypertension and the Russian Scientific Society of Cardiology (third revision). Cardiovascular Therapy and Prevention 2008; 6. Appendix 2: 1-32. Russian (Диагностика и лечение артериальной гипертензии. Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов (третий пересмотр). Кардиоваскулярная терапия и профилактика 2008; 6. Приложение 2: 1-32).

64. Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension. a systematic review. Hypertension 2009; 54: 1328-36.

65. Megnien J, Simon A, Denarie N, et al. Aortic stiffening does not predict coronary and extracoronary atherosclerosis in asymptomatic men at risk for cardiovascular disease. Am J Hypertens 1998; 11: 293-301.

66. Mitchell GF, Parise H, Benjamin EJ, et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension 2004; 43: 1239-45. doi: 10.1161/01. HYP.0000128420.01881.aa.

67. Mitchell GF, Wang N, Palmisano JN, et al. Hemodynamic correlates of blod pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study. Circulation 2010; 122: 1379-86. doi:10.1161/ CIRCULATIONAHA.109.914507.

68. Hummel BW, Hummel BA, Mowbry A, et al. Reactive hyperemia vs treadmill exercise testing in arterial disease. Arch Surg 1978; 113(1): 95-8.

69. Mitchell GF, Vita JA, Larson MG, et al. Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study. Circulation 2005; 112: 3722-8.

70. Lovett JK, Howard SC, Rothwell PM. Pulse pressure is independently associated with carotid plaque ulceration. J Hypertens 2003; 21: 1669-76.

71. Baumbach GL, Siems JE, Heistad DD. Effects of local reduction in pressure on distensibility and composition of cerebral arterioles. Circ Res 1991; 68: 338-51.

72. Baumbach GL. Effects of increased pulse pressure on cerebral arterioles. Hypertension 1996; 27: 159-67.

73. Christensen KL. Reducing pulse pressure in hypertension may normalize small artery structure. Hypertension 1991; 18: 722-7.

74. James MA, Watt PA, Potter JF, et al. Pulse pressure and esistance artery structure in the elderly. Hypertension 1995; 26: 301-6.

75. Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol 2008; 105: 1652-60.

76. Mitchell GF, van Buchem MA, Sigurdsson S, et al. Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility–Reykjavik study. Brain 2011; 134(pt 11): 3398-407.

77. Laurent S, Katsahian S, Fassot C, et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34: 1203-6.

78. Kass D, Saeki A, Tunun R, Recchia F. Adverse influence of systemic vascular stiffening on cardiac dysfunction and adaption to acute coronary occlusion. Circulation 1996; 93: 1533-41.

79. Watanabe H, Ohtsuka S, Kakihana M, Sugishita Y. Coronary circulation in dogs with an experimental decrease in aortic compliance. JACC 1993; 21: 1497-506.

80. Tomiyama H, Koij Y, Yambe M, et al. Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome. Circ J 2005; 69: 815-22.

81. Orlova YA, Kuzmina AE, Masenko VP, et al. Effect of arterial stiffness in the development of cardiovascular complications in coronary artery disease. Kardiologiia 2009; 12: 11-7. Russian (Орлова Я.А., Кузьмина А.Е., Масенко В.П. и др. Влияние жесткости артерий на развитие сердечно-сосудистых осложнений при ИБС. Кардиология 2009;12: 11-7).

82. Orlova YA, Nuralyev EY, Yarovaya EB, Ageev FT. Reduced arterial stiffness is associated with a favorable prognosis in men with coronary artery disease. Heart 2009; 8 (5): 261-5. Russian (Орлова Я.А., Нуралиев Э.Ю., Яровая Е.Б., Агеев Ф.Т. Снижение артериальной ригидности ассоциировано с благоприятным прогнозом у муж- чин с ИБС. Сердце 2009; 8(5): 261-5).

83. Miyoshi T, Doi M, Hirohata S, et al. Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with ischemic heart disease. J Atheroscler Thromb 2010;17 (3): 249-58.

84. Kadota K, Takamura N, Aoyagi K, et al. Avaliability of cardio-ankle vascular index (СAVI) as a scrining tool for atherosclerosis. Circ J 2008; 72: 304-8.

85. Izuhara M, Shioji K, Kadota S, et al. Relationship of cardio-ankle vascular index (СAVI) to carotid and coronary arteriosclerosis. Circ J 2008; 72 (11):1762-7.

86. Nakamura K, Tomaru T, Yamamura S, et al. Cardio-ankle vascular index is a candidate predictor of coronary atherosclerosis. Circ J 2008; 72: 598-604.

87. Laurent S, Cockcroft J, Van Bortel L, et al. on behalf of European Network for Non￾invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27: 2588-605.

88. Park HE, Choi SY, Kim MK. Oh B.N. Cardio-ankle vascular index reflects coronary atherosclerosis in patients with abnormal glucose metabolism: Assessment with 256 slice multi-detector computed tomography. J Cardiol 2012; 60(5): 372-6.

89. Sumin AN, Shcheglova AV, Fedorova NV, Bashtanova TB. Assessment of heart-ankle vascular index in cardio-vascular diseases. Methodical recommendations. Kemerovo 2014. Russian (Сумин А. Н., Щеглова А.В., Федорова Н.В., Баштанова Т.Б. Оценка сердечно-лодыжечного сосудистого индекса при кардиоваскулярных заболеваниях. Методические рекомендации. Кемерово 2014).

90. Hu H, Cui H, Han W, et al. A cutoff point for arterial stiffness using the cardio-ankle vascular index based on carotid arteriosclerosis. Hypertens Res 2013; 36 (4): 334-41.

91. Mineoka Y, Fukui M, Tanaka M, et al. Relationship between cardio-ankle vascular index (СЛСИ) and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus. Heart Vessels 2012; 27(2): 160-5.

92. Briet M, Pierre B, Laurent S, London GM. Arterial stiffness and pulse pressure in CKD and ESRD. Kidney Int 2012; 82: 388-400.

93. Georgianos PI, Sarafidis PA, Liakopoulos V. Arterial Stiffness: A Novel Risk Factor for Kidney Injury Progression? Am J Hypertens 2015; 28(8): 958-65.

94. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. JACC 2010; 55:1318-27.

95. Blacher J, Guerin AP, Pannier B, et al. Impact of aortic stiffness on survival in end￾stage renal disease. Circulation 1999; 99: 2434-9.

96. Bouchi R, Babazono T, Mugishima M, et al. Arterial stiffness is associated with incident albuminuria and decreased glomerular filtration rate in type 2 diabetic patients. Diabetes Care 2011; 34: 2570-5.

97. Briet M, Collin C, Karras A, et al. Arterial remodeling associates with CKD progression. J Am Soc Nephrol 2011; 22: 967-74.

98. Ford ML, Tomlinson LA, Chapman TP, et al. Aortic stiffness is independently associated with rate of renal function decline in chronic kidney disease stages 3 and 4. Hypertension 2010; 55: 1110-5.

99. Madero M, Peralta C, Katz R, et al. Association of arterial rigidity with incident kidney disease and kidney function decline: the Health ABC study. Clin J Am Soc Nephrol 2013; 8: 424-33.

100. O’Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005; 46: 200-20.

101. Townsend RR, Wimmer NJ, Chirinos JA, et al. Aortic PWV in chronic kidney disease: a CRIC ancillary study. Am J Hypertens 2010; 23: 282-9.

102. Weinberg I. Toe brachial index. Vascular medicine. 2012; http://www.angiologist. com/vascular-laboratory/toe-brachial-index.

103. Schaeffner ES, Kurth T, Bowman TS, et al. Blood pressure measures and risk of chronic kidney disease in men. Nephrol Dial Transplant 2008; 23: 1246-51.

104. Fesler P, Safar ME, du Cailar G, et al. Pulse pressure is an independent determinant of renal function decline during treatment of essential hypertension. J Hypertens 2007; 25: 1915-20.

105. Cohn JN, Finkelstein SM. Abnormalities of vascular compliance in hypertension, aging and heart failure. J Hypertens Suppl. 1992; 10(6): S61-4.

106. Lage SG, Kopel L, Monachini MC, et al. Carotid arterial compliance in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy. Аm J Cardiol 1994; 74(7): 691-5.

107. Ramsey MW, Goodfellow J, Jones CJ, et al. Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation 1995; 92(11): 3212-9.

108. Tsao CW, Lyass A, Larson MG, et al. Relation of Central Arterial Stiffness to Incident Heart Failure in the Community. J Am Heart Assoc 2015; 4: e002189.

109. Lopatin YM, Ilyukhin OV, Ilyukhina MV, et al. The elasticity of the arteries and pulse wave velocity in patients with chronic heart failure of various etiologies. Heart failure 2003; 5(4): 130-1. Russian (Лопатин Ю.М., Илюхин О.В., Илюхина М.В. и др. Эластичность артерий и скорость пульсовой волны у больных с хронической сердечной недостаточностью различной этиологии. Сердечная недостаточ- ность 2003;5(4):130-1).

110. Osmolovskaya YF, Mareev VY, Glechan AM, Balahonova TV. The value of arterial stiffness, central characteristics of the reflected wave and indicators vasomotor function of endothelial microvasculature in CHF of different etiology and severity of decompensation. Journal of Heart failure 2011; 12 (5): 270-6. Russian (Осмоловская Ю.Ф., Мареев В.Ю., Глечан А.М., Балахонова Т.В. Значение жесткости артерий, характеристик центральной отраженной волны и показателей вазомоторной функции эндотелия микроциркуляторного русла при ХСН различной этиологии и тяжести декомпенсации. Журнал Сердечная Недостаточность 2011;12(5): 270-6).

111. Chatzikyriakou SV, Tziakas D, Chalikias G, et al. Serum levels of collagen type-I degradation markers are associated with vascular stiffness in chronic heart failure patients. Eur Heart J 2008; 10(12): 1181-5.

112. Weber T, Ammer M, Rammer M, et al. Pulse waveform characteristics or central pressure indices to predict adverse cardiovascular outcomes in coronary patients. Artery Research 2008; 2(3): 90.

113. Ooi H, Chung W, Biolo A. Arterial stiffness and vascular load in heart failure. Congest Heart Fail 2008; 14: 31-6.

114. Hametner B, Weber T, Parragh S, et al. Impaired systolic function is associated with altered forward wave intensity. Artery Research 2014; 8(4): 136.

115. Her AY, Kim JY, Choi E-Y, et al. Value of Ventricular Stiffness Index and Ventriculoarterial Interaction in Patients With Nonischemic Dilated Cardiomyopathy. Circ J 2009; 73: 1683-90.

116. Lam CS, Roger VL, Rodeheffer RJ, et al. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation 2007; 115: 1982-90.

117. Wong RC, Dumont CA, Austin BA, et al. Relation of ventricular-vascular coupling to exercise capacity in ischemic cardiomyopathy: a cardiac multi-modality imaging study. Int J Cardiovasc Imaging. 2010; 26(2): 151-9.

118. Safar ME, O’Rourke MF. Arterial Stiffness in Hypertension. Amsterdam: Elsevier 2006; 23.

119. Fernandes VR, Polak JF, Cheng S, et al. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi‐Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 2008; 28: 194-201.

120. Meguro T1, Nagatomo Y, Nagae A, et al. Elevated arterial stiffness evaluated by brachial-ankle pulse wave velocity is deleterious for the prognosis of patients with heart failure. Circ J 2009; 73(4): 673-80. Epub 2009 Feb 27.

121. Demir S1, Akpınar O, Akkus O, et al. The prognostic value of arterial stiffness in systolic heart failure. Cardiology Journal 2013; 20(6): 665-71.

122. Zhang C, Ohira M, Iizuka T, et al. Cardio-ankle vascular index relates to left ventricular ejection fraction in patients with heart failure. A retrospective study. Int Heart J 2013; 54: 216-21.

123. Tartiere JM, Logeart D, Safar ME, A Cohen-Solal. Interaction between pulse wave velocity, augmentation index, pulse pressure and left ventricular function in chronic heart failure. J Hum Hypertens 2006; 20: 213-9.

124. Et-Taouil K, Safar M, Plante GE. Mechanisms and consequences of large artery rigidity. Can J Physiol Pharmacol 2003; 81: 205-11.

125. Peng X, Haldar S, Deshpande S, et al. Wall Stiffness suppresses Akt/eNOS and cytiprotection in pulse-perfused endothelium. Hypetension 2003; 41: 378-81.

126. Osmolovskaya YF, Mareev VY, Balahonova TV, et al. Arterial stiffness and endothelial dysfunction indicators microcircular bed in CHF patients with preserved and reduced left ventricular contractile function. Journal of Heart failure 2011; 12(3): 142-8. Russian (Осмоловская Ю. Ф., Мареев В.Ю., Балахонова Т.В. и др. Артериальная жесткость и показатели эндотелиальной дисфункции микроциркулярного русла у больных ХСН с сохраненной и сниженной сократительной функцией миокарда левого желудочка. Журнал Сердечная Недостаточность 2011; 12(3): 142-8).

127. Tartiere JM, Logeart D, Safar ME, A Cohen-Solal. Interaction between pulse wave velocity, augmentation index, pulse pressure and left ventricular function in chronic heart failure. J Hum Hypertens 2006; 20: 213-9.

128. Lage SG, Kopel L, Monachini MC, et al. Carotid arterial compliance in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy. Аm J Cardiol 1994; 74(7): 691-5.

129. Giannattasio C, Achilli F, Failla M, et al. Radial, carotid and aortic distensibility in congestive heart failure: effects of high-dose angiotensinconverting enzyme inhibitor or low-dose association with angiotensin type1 receptor blockade. JACC 2002; 39: 1275-82.

130. Lage SG, Kopel L, Monachini MC, et al. Carotid arterial compliance in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol 1994; 74: 691-5.

131. Nakamura M, Sugawara S, Arakawa N, et al. Reduced vascular compliance is associated with impaired endothelium-dependent dilatation in the brachial artery of patients with congestive heart failure. J Card Fail 2004; 10: 36-42.

132. Rerkpattanapipat P, Hundley WG, Link KM,. et al. Relation of aortic distensibility determined by magnetic resonance imaging in patients > or =60 years of age to systolic heart failure and exercise capacity. Am J Cardiol 2002; 90:1221-5.

133. Peters MJ, Symmons DP, McCarey DW, et al. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other types of inflammatory arthritis — TASK FORCE “Cardiovascular risk management in RA”. Ann Rheum Dis 2010; 69: 325-31.

134. Meune C, Touze E, Trinqurte L, Allanore Y. Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta￾analysis of cohort studies. Rheumatology 2009; 48: 1309-13.

135. Gabriel SE. Why do people with rheumatoid arthritis still die prematurely? Ann Rheum. Dis 2008; 67 (Suppl 3): 30-4.

136. Meune C, Touzé E, Trinquart L, Allanore Y. High risk of clinical cardiovascular events in RA: levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis. Arch Cardiovasc Dis 2010; 103: 253-61.

137. van Halm VP, Peters MJ, Voskuyl AE, et al. Rheumatoid arthritis versus type 2 diabetes as a risk factor for cardiovascular disease: a cross-sectional study. Ann Rheum Dis 2009; 68: 1395-400.

138. Holmqvist ME, Wedrén S, Jacobsson LT, et al. Rapid increase in myocardial infarction risk following diagnosis of RA amongst patients diagnosed between 1995 and 2006. J Intern Med 2010; 268: 578-85.

139. Crowson CS, Gabriel SE. Towards improving cardiovascular risk management in patients with rheumatoid arthritis: the need for accurate risk assessment. Ann Rheum Dis 2011; 70(5): 719-21.

140. Gasparyan AY, Stavropoulos-Kalinoglou A, Mikhailidis DP, et al. The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases. Curr Vasc Pharmacol 2010; 8: 437-49.

141. Maki-Petaja KM, Hall FC, Booth AD, et al. Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor￾alpha therapy. Circulation 2006; 114: 1185-92.

142. Ambrosino P, Tasso M, Lupoli R, et al. Non-invasive assessment of arterial stiffness in patients with rheumatoid arthritis: A systematic review and meta-analysis of literature studies. Ann Med 2015; 47: 457-67.

143. Provan SA, Angel K, Odegård S, et al. Early inflammation can predict arterial stiffness: a 5-year longitudinal study of 238 patients with rheumatoid arthritis. Ann Rheum Dis 2008; 67 (suppl II): 310.

144. Wong M, Oakley SP, Young L, et al. Infliximab improves vascular stiffness in patients with rheumatoid arthritis. Ann Rheum Dis 2009; 68: 1277-84.

145. Angel K, Provan SA, Fagerhol MK, et al. Effect of 1-year anti-TNF-alpha therapy on aortic stiffness, carotid atherosclerosis, and calprotectin in inflammatory arthropathies: a controlled study. Am J Hypertens 2012; 25(6): 644-50.

146. Provan SA, Berg IJ, Hammer HB, et al. The Impact of newer biological disease modifying anti-rheumatic drugs on cardiovascular risk factors: A 12-month longitudinal study in rheumatoid arthritis patients treated with rituximab, abatacept and tociliziumab. PLoS ONE 2015;10(6): e0130709.

147. Hedwig E. Reference Range pulse wave velocity on the aorta in healthy children aged from 3 to 18 years in the book: E. Hidvegi, Iyesh M., B. Bentsur, RM barrels Radgeber L, J. Lecca, FT Molnar, A. Tsiraki. Pediatric pharmacology 2013; 10(2): 64-71. Russian (Хидвеги E. Референтные значения скорости распространения пульсовой волны по аорте у здоровых детей в возрасте от 3 до 18 лет. В кн: Е. Хидвеги, М. Ийеш, Б. Бенцур, Р.М. Бочке, Л. Радгебер, Ж. Леккеи, Ф.Т. Молнар, А. Цираки. Педиатрическая фармакология 2013; 10(2): 64-71).

148. Li S, Chen W, Srinivasan SR, Berenson GS. Childhood blood pressure as a predictor of arterial stiffness in young adults: the Bogalusa Heart Study. Hypertension 2004; 43: 541-6. doi: 10.1161/01. HYP.0000115922.98155.23.

149. Koivistoinen T, Hutri-Kahonen N, Juonala M, et al. Metabolic syndrome in childhood and increased arterial stiffness in adulthood: the Cardiovascular Risk in Young Finns Study. Ann Med 2011; 43: 312-9. doi: 10.3109/07853890.2010.549145.

150. Aatola H, Koivistoinen T, Hutri-Kahonen N, et al. Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2010; 122: 2521-8. doi: 10.1161/ CIRCULATIONAHA.110.969279.

151. Kyvelou SM, Vyssoulis GP, Karpanou EA, et al. Arterial hypertension parental burden affects arterial stiffness and wave reflection to the aorta in young offsprings. Int J Cardiol 2010; 144: 156-60. doi: 10.1016/j. ijcard.2008.12.154.

152. Kucerova J, Filipovsky J, Staessen JA, et al. Arterial characteristics in normotensive offspring of parents with or without a history of hypertension. Am J Hypertens 2006; 19: 264-9. doi: 10.1016/j.amjhyper.2005.09.015. 155. Riggio S, Mandraffino G, Sardo MA, et al. Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children. Eur J Clin Invest 2010; 40: 250-7. doi: 10.1111/j.1365- 2362.2010.02260.x.

153. Wadwa RP, Urbina EM, Anderson AM, et al.; SEARCH Study Group. Measures of arterial stiffness in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study. Diabetes Care 2010; 33: 881-6. doi: 10.2337/dc09-0747.

154. Blacher J, Guerin AP, Pannier B, et al. Impact of aortic stiffness on survival in end￾stage renal disease. Circulation 1999; 99: 2434-9.

155. Dietz LJ, Matthews KA. Depressive symptoms and subclinical markers of cardiovascular disease in adolescents. J Adolesc Health 2011; 48: 579-84. doi: 10.1016/j.jadohealth.2010.09.001.

156. Midei AJ, Matthews KA. Social relationships and negative emotional traits are associated with central adiposity and arterial stiffness in healthy adolescents. Health Psychol 2009; 28: 347-53. doi: 10.1037/a0014214.

157. Thurston RC, Matthews KA. Racial and socioeconomic disparities in arterial stiffness and intima media thickness among adolescents. Soc Sci Med 2009; 68: 807-13. doi: 10.1016/j.socscimed.2008.12.029.

158. van de Laar RJ, Stehouwer CD, Boreham CA, et al. Continuing smoking between adolescence and young adulthood is associated with higher arterial stiffness in young adults: the Northern Ireland Young Hearts Project. J Hypertens 2011; 29: 2201-9.

159. Chen Y, Dangardt F, Osika W, et al. Ageand sex-related differences in vascular function and vascular response to mental stress: longitudinal and cross-sectional studies in a cohort of healthy children and adolescents. Atherosclerosis 2012; 220: 269-74. doi: 10.1016/j.atherosclerosis.2011.10.030.

160. Edwards NM, Daniels SR, Claytor RP, et al. Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults. Metabolism 2012; 61: 869-72. doi: 10.1016/j.metabol.2011.10.016.