Cardiac sarcoidosis: is early diagnosis possible? Case report
https://doi.org/10.15829/1728-8800-2022-3448
Abstract
Cardiac involvement in sarcoidosis is difficult to diagnose due to the asymptomatic course in 95% of cases, the inaccessibility and low information content of a heart biopsy, the absence of pathological disorders in routine examination methods or their non-specificity. At the same time, it is cardiac sarcoidosis, along with damage to the nervous system, that is the main cause of mortality in sarcoidosis. Early diagnosis is of decisive importance for preventing complications associated with heart involvement and choosing the right treatment tactics. The positron emission tomography-computed tomography (PET-CT) is a method that can help the doctor in assessing the prevalence of sarcoidosis and verifying latent localizations in patients with a morphologically confirmed disease. The article describes a case of the use of PET/CT for the diagnosis of cardiac sarcoidosis.
About the Authors
D. N. Antipushina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Moscow
A. A. Zaitsev
N.N. Burdenko Main Military Clinical Hospital
Russian Federation
Russian Federation
Moscow
P. G. Shakhnovich
Central Clinical Hospital with a Polyclinic
Russian Federation
Russian Federation
Moscow
S. A. Chernov
N.N. Burdenko Main Military Clinical Hospital
Russian Federation
Russian Federation
Moscow
S. I. Kurbanov
N.N. Burdenko Main Military Clinical Hospital
Russian Federation
Russian Federation
Moscow
D. N. Kazantsev
N.N. Burdenko Main Military Clinical Hospital
Russian Federation
Russian Federation
Moscow
References
1. Shabalin VV, Grinshteyn YuI. Cardiac sarcoidosis: modern diagnostics and therapy. Russian Journal of Cardiology. 2020;25(11):4052. (In Russ.) doi:10.15829/29/1560-4071-20204052.
2. Houston BA, Mukherjee M. Cardiac sarcoidosis: clinical manifestations, imaging characteristics, and therapeutic approach. Clin Med Insights Cardiol. 2014;8 (Suppl 1):31-7. doi:10.4137/CMC.S15713.
3. Serova MV, Poltavskaya MG, Garmash YuYu, et al. Complete atrioventricular block as a clinical manifestation of cardiac sarcoidosis. Russian Journal of Cardiology. 2019;(11):63-8. (In Russ.) doi:10.15829/1560-4071-2019-11-63-68.
4. Saric P, Young KA, Rodriguez-Porcel M, et al. PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers. Pharmaceuticals (Basel). 2021;14(12):1286. doi:10.3390/ph14121286.
5. Antipushina DN, Kryukov EV, Shakhnovich PG, et al. Cardiac sarcoidosis: clinical manifestations, modern diagnostics, and treatment. Voenno-medicinskij žurnal. 2019;340(8):24-9. (In Russ.) doi:10.17816/RMMJ81924.
6. Yazaki Y, Isobe M, Hiroe M, et al. Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. Am J Cardiol. 2001;88(9):1006-10. doi:10.1016/s0002-9149(01)01978-6.
7. Lagana SM, Parwani AV, Nichols LC. Cardiac sarcoidosis: a pathology-focused review. Arch Pathol Lab Med. 2010;134(7):1039-46. doi:10.5858/2009-0274-RA.1.
8. Chapelon-Abric C. Cardiac sarcoidosis. Curr Opin Pulm Med. 2013;19(5):493-502. doi:10.1097/MCP.0b013e32836436da.
9. Zaitsev AA, Antipushina DN, Sivokozov IV. Practical possibilities of PET/CT in assessing the activity and prevalence of sarcoidosis. Pulmonology. 2013;6:119-22. (In Russ.) doi:10.18093/0869-0189-2013-0-6-119-122.
10. Skali H, Schulman A, Dorbala S. 18F-FDG PET/CT for the assessment of myocardial sarcoidosis. Curr Cardiol Rep. 2013;15(4):352.
11. Soussan M, Augier A, Brillet PY, et al. Functional imaging in extrapulmonary sarcoidosis: FDG-PET/CT and MR features. Clin Nucl Med. 2014;39(2):e146-59. doi:10.1097/RLU.0b013e318279f264.
12. Akaike G, Itani M, Shah H, et al. PET/CT in the Diagnosis and Workup of Sarcoidosis: Focus on Atypical Manifestations. Radiographics. 2018;38(5):1536-49. doi:10.1148/rg.2018180053.
Supplementary files
Review
For citations:
Antipushina D.N., Zaitsev A.A., Shakhnovich P.G., Chernov S.A., Kurbanov S.I., Kazantsev D.N. Cardiac sarcoidosis: is early diagnosis possible? Case report. Cardiovascular Therapy and Prevention. 2022;21(12):3448. (In Russ.) https://doi.org/10.15829/1728-8800-2022-3448
Views:
1042
Email this article 
