Preview

Cardiovascular Therapy and Prevention

Advanced search

Cardiovascular complications in non-cardiac surgery: what remains out of sight?

https://doi.org/10.15829/1728-8800-2024-3748

EDN: HYXPTE

Abstract

Aim. To evaluate any cardiovascular abnormalities in the postoperative period, their prevalence and impact on the course of postoperative period in patients after non-cardiac surgery, which underwent postoperative examinations of cardiovascular system.

Material and methods. The study included 2937 patients. The assessed end points were postoperative cardiovascular events (CVEs). Along with major adverse cardiovascular events (MACE), we analyzed any cardiovascular abnormalities in the postoperative period as follows: electrocardiographic ST-T abnormalities, acute or decompensated heart failure (HF), arrhythmias, episodes of hypotension or hypertension, bleeding, thromboembolic events (TEEs), cerebrovascular events, postoperative delirium. Any CVEs constituted the any cardiovascular events' (ACVEs) group. Statistical analysis was carried out using the StatTech v program. 3.1.6 (OOO Stattekh, Russia).

Results. Any postoperative complications according to the Clavien-Dindo classification were 54,7%, while grade 1 — 33,9%, grade 2 — 20,3%, grade 3 — 1 case, grade 4 — 0,4%, grade 5 — 0,1%. MACEs developed in 0,2% of cases. ACVEs amounted to 13,3%, including 2,3% — ST-T abnormalities, 6,3% — significant systolic blood pressure changes, 2,6% — arrhythmias, 0,7% — HF, 2,4% — bleeding, 1,1% — TEEs, 0,3% — delirium. In addition, 67 (17,5%) patients had ≥2 CVEs. Comparison of the length of hospital stay of patients with ACVEs, in particular with MACEs, ECG ST-T abnormalities, HF, arrhythmia, episodes of hypotension or hypertension, bleeding, TEEs, cerebrovascular events, delirium, with groups of patients without such complications revealed significant differences. ACVEs accounted for 1/4 of all postoperative complications and 2/3 of complications of grades 2-5.

Conclusion. We expanded the concept of CVEs, united the totality of any cardiovascular abnormalities in the postoperative period, emphasized not only their clinical significance, but also the economic feasibility of taking into account ACVEs.

About the Authors

S. S. Murashko
United Hospital with Clinic of the Administrative Directorate of the President of the Russian Federation; Central State Medical Academy
Russian Federation

Moscow



S. A. Berns
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow



I. N. Pasechnik
Central State Medical Academy
Russian Federation

Moscow



References

1. Murashko SS, Pasechnik IN, Berns SA. Cardiovascular complications in non-cardiac surgery: what do we know? Kremlinmedicine. 2019;4:90-7. (In Russ.) doi:10.26269/rg71-m772.

2. Manekk RS, Gharde P, Gattani R, et al. Surgical Complications and Its Grading: A Literature Review. Cureus. 2022;14(5):e24963. doi:10.7759/cureus.24963.

3. Patel AS, Bergman A, Moore BW, et al. The economic burden of complications occurring in major surgical procedures: a systematic review. Appl Health Econ Health Policy. 2013;11:577-92. doi:10.1007/s40258-013-0060-y.

4. Cen N, Hollier LH Jr. Review of "Clinical Validation of the Comprehensive Complication Index as a Measure of Postoperative Morbidity at a Surgical Department: A Prospective Study" by Roberto PL, et al in Ann Surg 268:838-844, 2018. J Craniofac Surg. 2019;30(6):1921. doi:10.1097/SCS.0000000000005291.

5. Bosco E, Hsueh L, McConeghy KW, et al. Major adverse cardiovascular event definitions used in observational analysis of administrative databases: a systematic review. BMC Med Res Methodol. 2021;21(1):241. doi:10.1186/s12874-021-01440-5.

6. Smilowitz NR, Berger JS. Perioperative Cardiovascular Risk Assessment and Management for Noncardiac Surgery: A Review. JAMA. 2020;324(3):279-90. doi:10.1001/jama.2020.7840.

7. Peterson BR, Cotton A, Foy AJ. Reevaluating the Cardiac Risk of Noncardiac Surgery Using the National Surgical Quality Improvement Program. Am J Med. 2021;134(12):1499-505. doi:10.1016/j.amjmed.2021.07.016.

8. Devereaux PJ, Goldman L, Cook DJ, et al. Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ. 2005;173(6):627-34. doi:10.1503/cmaj.050011.

9. Smilowitz NR, Gupta N, Ramakrishna H, et al. Perioperative Major Adverse Cardiovascular and Cerebrovascular Events Associated With Noncardiac Surgery. JAMA Cardiol. 2017;2(2):181-7. doi:10.1001/jamacardio.2016.4792.

10. Sumin AN. Assessment and Correction of the Cardiac Complications Risk in Non-cardiac Operations — What's New? Rational Pharmacotherapy in Cardiology 2022;18(5):591-9. (In Russ.) doi:10.20996/1819-6446-2022-10-04.

11. Spence J, LeManach Y, Chan MTV, et al. Association between complications and death within 30 days after noncardiac surgery. CMAJ. 2019;191:E830-7. doi:10.1503/cmaj.190221.

12. Chomakhidze PS, Mozzhuhina NV, Poltavskaya MG, et al. Functional Diagnostic Methods in Cardiac Prognosis in Major Abdo minal Surgery in Patients with Heart Disease or Over 65 Years Old. Kardiologiia. 2019;59(1):69-78. (In Russ.) doi:10.18087/cardio.2019.1.10210.

13. Puelacher C, Lurati Buse G, Seeberger D, et al. Perioperative Myocardial Injury After Noncardiac Surgery: Incidence, Mortality, and Characterization. Circulation. 2018;137(12):1221-32. doi:10.1161/CIRCULATIONAHA.117.030114.

14. AlTurki A, Marafi M, Proietti R, et al. Major Adverse Cardiovascular Events Associated With Postoperative Atrial Fibrillation After Noncardiac Surgery: A Systematic Review and Meta-Analysis. Circ Arrhythm Electrophysiol. 2020;13(1):e007437. doi:10.1161/CIRCEP.119.007437.

15. Lin MH, Kamel H, Singer DE, et al. Perioperative/Postoperative Atrial Fibrillation and Risk of Subsequent Stroke and/or Mortality. Stroke. 2019;50(6):1364-71. doi:10.1161/STROKEAHA.118.023921.

16. Dobrev D, Aguilar M, Heijman J, et al. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. 2019;16(7):417-36. doi:10.1038/s41569-019-0166-5.

17. Sessler DI, Khanna AK. Perioperative myocardial injury and the contribution of hypotension. Intensive Care Med. 2018;44(6):811-22. doi:10.1007/s00134-018-5224-7.

18. Filipescu DC, Stefan MG, Valeanu L, et al. Perioperative management of antiplatelet therapy in noncardiac surgery. Curr Opin Anaesthesiol. 2020;33(3):454-62. doi:10.1097/ACO.0000000000000875.

19. Murashko SS, Pasechnik IN, Berns SA. Prediction of thromboembolic complications in non-cardiac surgery. Kremlin-medicine. 2023;3:8-12. (In Russ.) doi:10.48612/cgma/r6m6-9p9z-d4nd.

20. Smilowitz NR, Gupta N, Guo Y, et al. Trends in Perioperative Venous Thromboembolism Associated with Major Noncardiac Surgery. TH Open. 2017;1(2):e82-91. doi:10.1055/s-0037-1605360.

21. Likhvantsev VV, Ulitkina ON, Rezepov NA. Postoperative delirium: what new does novel guidelines by ESA-2017 offer? Messenger of anesthesiology and resuscitation. 2017;14(2):41-7. (In Russ.) doi:10.21292/2078-5658-2017-14-2-41-47.


Supplementary files

What is already known about the subject?

  • Major adverse cardiac events (MACEs) do not make it possible to assess the significance of all car­diovascular events after non-cardiac surgery.

What might this study add?

  • For the first time, combining any cardiovascular abnormalities in the postoperative period into the any cardio-­vascular events’ (ACVEs) category.
  • ACVEs account for 1/4 of all postoperative compli­cations and 2/3 of Clavien-­Dindo grade 2-5 com­plications.
  • ACVEs are associated with increased length of stay and economic costs.

Review

For citations:


Murashko S.S., Berns S.A., Pasechnik I.N. Cardiovascular complications in non-cardiac surgery: what remains out of sight? Cardiovascular Therapy and Prevention. 2024;23(1):3748. (In Russ.) https://doi.org/10.15829/1728-8800-2024-3748. EDN: HYXPTE

Views: 617


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)