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Dyslipidemia in the Russian Federation: population data, associations with risk factors

https://doi.org/10.15829/1728-8800-2023-3791

EDN: DGYJLA

Abstract

Aim. To study the prevalence of dyslipidemias and their association with various risk factors in the Russian population of men and women aged 35-74 years in 2020-2022.

Material and methods. This work was carried out as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study. The sample included 28731 men and women aged 35-74 years living in 15 Russian regions. Hypercholesterolemia (HC) was diagnosed with total cholesterol (TC) ≥5,0 mmol/l, while elevated low-density lipoprotein cholesterol (LDL-C) was considered ≥3,0 mmol/l, hypertriglyceridemia — with triglyceride levels ≥1,7 mmol/l, reduced high-density lipoprotein cholesterol (HDL-C) <1,0 mmol/l in men and <1,2 mmol/l in women. Associations were assessed using logistic regression after adjustment for socio-demographic characteristics, drinking status, presence of hypertension (HTN) and stroke.

Results. The prevalence of hypertriglyceridemia in the Russian Federation in 2020-2022 was 58,8%, hypertriglyceridemia — 32,2%. The incidence of lipid-lowering therapy increased with age from 1% in the group of 35-44 years to 16% in the group of 65-74 years. On average, only 7,6% of study participants received lipid-lowering therapy. Significant associations of HC with HTN, obesity and alcohol abuse were identified. Similar results were obtained for elevated LDL-C levels, with the exception of alcohol abuse. In turn, a reduced HDL-C level was significantly associated with the lack of higher education, marriage, physical activity, smoking and the presence of diseases.

Conclusion. The prevalence of lipid disorders in the Russian Federation in 2020-2022 remained at a high level. These disorders occurred more often in women, and they were better informed about their cholesterol levels and more often received lipid-lowering therapy. HTN, obesity, and some behavioral and social risk factors were associated with dyslipidemia.

About the Authors

O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


A. E. Imaeva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


V. A. Kutsenko
National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University
Russian Federation

Moscow


A. V. Kapustina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


Yu. A. Balanova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


S. A. Maksimov
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


G. A. Muromtseva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


M. B. Kotova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


N. S. Karamnova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


S. E. Evstifeeva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


O. A. Litinskaya
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


M. S. Pokrovskaya
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


N. A. Imaeva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


E. M. Filichkina
National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University
Russian Federation

Moscow


O. E. Ivlev
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


G. E. Svinin
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


L. I. Gomanova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


Yu. V. Doludin
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


I. A. Efimova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


A. L. Borisova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


B. M. Nazarov
City Polyclinic № 109
Russian Federation

Moscow


E. B. Yarovaya
National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University
Russian Federation

Moscow


T. V. Repkina
Regional Center for Public Health and Medical Prevention
Russian Federation

Barnaul


T. O. Gonoshilova
Regional Center for Public Health and Medical Prevention
Russian Federation

Barnaul


A. V. Kudryavtsev
Northern State Medical University
Russian Federation

Arkhangelsk


N. I. Belova
Northern State Medical University
Russian Federation

Arkhangelsk


L. L. Shagrov
Northern State Medical University
Russian Federation

Arkhangelsk


M. A. Samotrueva
Astrakhan State Medical University
Russian Federation

Astrakhan


A. L. Yasenyavskaya
Astrakhan State Medical University
Russian Federation

Astrakhan


E. N. Chernysheva
Astrakhan State Medical University
Russian Federation

Astrakhan


S. V. Glukhovskaya
Sverdlovsk Regional Medical College
Russian Federation

Ekaterinburg


I. A. Levina
Sverdlovsk Regional Medical College
Russian Federation

Ekaterinburg


E. A. Shirshova
Sverdlovsk Regional Medical College
Russian Federation

Ekaterinburg


E. B. Dorzhieva
Boyanov Center for Public Health and Medical Prevention
Russian Federation

Ulan-Ude


E. Z. Urbanova
Boyanov Center for Public Health and Medical Prevention

Ulan-Ude


N. Yu. Borovkova
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod


V. K. Kurashin
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod


A. S. Tokareva
Privolzhsky Research Medical University
Russian Federation

Nizhny Novgorod


Yu. I. Ragino
Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics
Russian Federation

Novosibirsk


G. I. Simonova
Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics
Russian Federation

Novosibirsk


V. S. Shramko
Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics
Russian Federation

Novosibirsk


V. N. Nikulin
Orenburg Regional Center for Public Health and Medical Prevention
Russian Federation

Orenburg


O. R. Aslyamov
Orenburg Regional Center for Public Health and Medical Prevention
Russian Federation

Orenburg


G. V. Khokhlova
Orenburg Regional Center for Public Health and Medical Prevention
Russian Federation

Orenburg


A. V. Solovyova
Tver State Medical University
Russian Federation

Tver


A. A. Rodionov
Tver State Medical University
Russian Federation

Tver


O. V. Kryachkova
Tver State Medical University
Russian Federation

Tver


Yu. Yu. Shamurova
South Ural State Medical University
Russian Federation

Chelyabinsk


I. V. Tantsyreva
South Ural State Medical University
Russian Federation

Chelyabinsk


I. N. Baryshnikova
South Ural State Medical University
Russian Federation

Chelyabinsk


M. G. Ataev
Abusuev Research Institute of Environmental Medicine, Dagestan State Medical University
Russian Federation

Makhachkala


M. O. Radjabov
Abusuev Research Institute of Environmental Medicine, Dagestan State Medical University
Russian Federation

Makhachkala


M. M. Isakhanova
Abusuev Research Institute of Environmental Medicine, Dagestan State Medical University
Russian Federation

Makhachkala


M. A. Umetov
Berbekov Kabardino-Balkarian State University
Russian Federation

Nalchik


L. V. Elgarova
Berbekov Kabardino-Balkarian State University
Russian Federation

Nalchik


I. A. Khakuasheva
Berbekov Kabardino-Balkarian State University
Russian Federation

Nalchik


E. I. Yamashkina
Ogarev Mordovian State University
Russian Federation

Saransk


M. V. Esina
Ogarev Mordovian State University
Russian Federation

Saransk


T. A. Kunyaeva
Ogarev Mordovian State University; Mordovian Republican Central Clinical Hospital
Russian Federation

Saransk


A. M. Nikitina
Republican Center for Public Health and Medical Prevention
Russian Federation

Yakutsk


N. V. Savvina
Ammosov North-Eastern Federal University
Russian Federation

Yakutsk


Yu. E. Spiridonova
Republican Center for Public Health and Medical Prevention
Russian Federation

Yakutsk


E. A. Naumova
Republican Center for Public Health and Medical Prevention, Exercise therapy and Sports Medicine
Russian Federation

Cheboksary


A. A. Keskinov
Center for Strategic Planning and Management of Biomedical Health Risks
Russian Federation

Moscow


V. S. Yudin
Center for Strategic Planning and Management of Biomedical Health Risks
Russian Federation

Moscow


S. M. Yudin
Center for Strategic Planning and Management of Biomedical Health Risks
Russian Federation

Moscow


A. V. Kontsevaya
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


S. A. Shalnova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


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Supplementary files

What is already known about the subject?

  • The results of numerous studies indicate that dyslipidemias make a significant contribution to atherosclerotic cardiovascular diseases and are associated with significant economic damage.
  • Currently, there are no data on the prevalence of dyslipidemia in the Russian Federation, as well as their relationship with cardiovascular risk fac­tors.

What might this study add?

  • The prevalence of hypercholesterolemia in the Russian Federation in 2020-2022 was 58,8%, hyper­triglyceridemia — 32,2%.
  • Women are more informed about their cholesterol levels and are more likely to receive lipid-­lowering therapy compared to men. Although the proportion of persons receiving lipid-­lowering therapy increased with age, it accounted for only 7,6% of the general population.
  • Hypertension, obesity, behavioral and social risk factors were significantly associated with dyslipi­demia.

Review

For citations:

Drapkina O.M., Imaeva A.E., Kutsenko V.A., Kapustina A.V., Balanova Yu.A., Maksimov S.A., Muromtseva G.A., Kotova M.B., Karamnova N.S., Evstifeeva S.E., Litinskaya O.A., Pokrovskaya M.S., Imaeva N.A., Filichkina E.M., Ivlev O.E., Svinin G.E., Gomanova L.I., Doludin Yu.V., Efimova I.A., Borisova A.L., Nazarov B.M., Yarovaya E.B., Repkina T.V., Gonoshilova T.O., Kudryavtsev A.V., Belova N.I., Shagrov L.L., Samotrueva M.A., Yasenyavskaya A.L., Chernysheva E.N., Glukhovskaya S.V., Levina I.A., Shirshova E.A., Dorzhieva E.B., Urbanova E.Z., Borovkova N.Yu., Kurashin V.K., Tokareva A.S., Ragino Yu.I., Simonova G.I., Shramko V.S., Nikulin V.N., Aslyamov O.R., Khokhlova G.V., Solovyova A.V., Rodionov A.A., Kryachkova O.V., Shamurova Yu.Yu., Tantsyreva I.V., Baryshnikova I.N., Ataev M.G., Radjabov M.O., Isakhanova M.M., Umetov M.A., Elgarova L.V., Khakuasheva I.A., Yamashkina E.I., Esina M.V., Kunyaeva T.A., Nikitina A.M., Savvina N.V., Spiridonova Yu.E., Naumova E.A., Keskinov A.A., Yudin V.S., Yudin S.M., Kontsevaya A.V., Shalnova S.A. Dyslipidemia in the Russian Federation: population data, associations with risk factors. Cardiovascular Therapy and Prevention. 2023;22(8S):3791. (In Russ.) https://doi.org/10.15829/1728-8800-2023-3791. EDN: DGYJLA

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ISSN 1728-8800 (Print)
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